| Open loop-gain of the CO2 ventilatory control system. | |
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MedLine Citation:
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PMID: 3934795 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We devised a method of measuring the open-loop gain for CO2-ventilatory feedback control system. The procedure is to gradually increase then decrease the PICO2 while measuring PICO2 and PACO2. We theorized that the gain is delta PICO2/delta PACO2-1. We measured this gain in 11 young healthy subjects and found the value to be 3.24, quite different from what had been reported so far by a conventional method. The conventional method calculates the gain as the ratio of the slope of CO2-response curve(s) over that of metabolic hyperbola. Analysis revealed that the conventional method requires an accurate knowledge of s-value at the very operating point. The assumption that the CO2 response curve is linear down to the operating point is probably the source of error. The open-loop gain for CO2 ventilatory control is in the order of 3, from which we may extrapolate that the slope of CO2-response curve at the operating point is much flatter than the normal value of more than 21/min/mmHg. |
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Authors:
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K Suwa; F Matsushita |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Tohoku journal of experimental medicine Volume: 147 ISSN: 0040-8727 ISO Abbreviation: Tohoku J. Exp. Med. Publication Date: 1985 Sep |
Date Detail:
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Created Date: 1986-01-21 Completed Date: 1986-01-21 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0417355 Medline TA: Tohoku J Exp Med Country: JAPAN |
Other Details:
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Languages: eng Pagination: 97-106 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Carbon Dioxide / administration & dosage, physiology* Feedback Humans Male Pulmonary Gas Exchange Respiration* |
| Chemical | |
Reg. No./Substance:
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124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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