Document Detail

Open loop-gain of the CO2 ventilatory control system.
MedLine Citation:
PMID:  3934795     Owner:  NLM     Status:  MEDLINE    
We devised a method of measuring the open-loop gain for CO2-ventilatory feedback control system. The procedure is to gradually increase then decrease the PICO2 while measuring PICO2 and PACO2. We theorized that the gain is delta PICO2/delta PACO2-1. We measured this gain in 11 young healthy subjects and found the value to be 3.24, quite different from what had been reported so far by a conventional method. The conventional method calculates the gain as the ratio of the slope of CO2-response curve(s) over that of metabolic hyperbola. Analysis revealed that the conventional method requires an accurate knowledge of s-value at the very operating point. The assumption that the CO2 response curve is linear down to the operating point is probably the source of error. The open-loop gain for CO2 ventilatory control is in the order of 3, from which we may extrapolate that the slope of CO2-response curve at the operating point is much flatter than the normal value of more than 21/min/mmHg.
K Suwa; F Matsushita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  147     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  97-106     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / administration & dosage,  physiology*
Pulmonary Gas Exchange
Reg. No./Substance:
124-38-9/Carbon Dioxide

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