| Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease. | |
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MedLine Citation:
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PMID: 20129486 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Parkinson's disease (PD) is a progressive neurodegenerative disease for which stem cell research has created hope in the last few years. Seven PD patients aged 22 to 62 years with a mean duration of disease 14.7+/-7.56 years were enrolled to participate in the prospective, uncontrolled, pilot study of single-dose, unilateral transplantation of autologous bone-marrow-derived mesenchymal stem cells (BM-MSCs). The BM-MSCs were transplanted into the sublateral ventricular zone by stereotaxic surgery. Patients were followed up for a period that ranged from 10 to 36 months. The mean baseline "off" score was 65+/-22.06, and the mean baseline "on" score was 50.6+/-15.85. Three of 7 patients have shown a steady improvement in their "off"/"on" Unified Parkinson's Disease Rating Scale (UPDRS). The mean "off" score at their last follow-up was 43.3 with an improvement of 22.9% from the baseline. The mean "on" score at their last follow-up was 31.7, with an improvement of 38%. Hoehn and Yahr (H&Y) and Schwab and England (S&E) scores showed similar improvements from 2.7 and 2.5 in H&Y and 14% improvement in S&E scores, respectively. A subjective improvement was found in symptoms like facial expression, gait, and freezing episodes; 2 patients have significantly reduced the dosages of PD medicine. These results indicate that our protocol seems to be safe, and no serious adverse events occurred after stem-cell transplantation in PD patients. The number of patients recruited and the uncontrolled nature of the trial did not permit demonstration of effectiveness of the treatment involved. However, the results encourage future trials with more patients to demonstrate efficacy. |
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Authors:
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Neelam K Venkataramana; Satish K V Kumar; Sudheer Balaraju; Radhika Chemmangattu Radhakrishnan; Abhilash Bansal; Ashish Dixit; Deepthi K Rao; Madhulita Das; Majahar Jan; Pawan Kumar Gupta; Satish M Totey |
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Publication Detail:
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Type: Clinical Trial; Journal Article Date: 2009-08-06 |
Journal Detail:
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Title: Translational research : the journal of laboratory and clinical medicine Volume: 155 ISSN: 1878-1810 ISO Abbreviation: Transl Res Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-04 Completed Date: 2010-03-01 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101280339 Medline TA: Transl Res Country: United States |
Other Details:
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Languages: eng Pagination: 62-70 Citation Subset: AIM; IM |
Copyright Information:
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(c) 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Advanced Neuroscience Institute, BGS-Global Hospital, Bangalore, India. drnkvr@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bone Marrow Cells / cytology* Cells, Cultured Feasibility Studies Follow-Up Studies Humans Immunophenotyping Magnetic Resonance Imaging Male Mesenchymal Stem Cell Transplantation* / adverse effects Middle Aged Parkinson Disease / pathology, surgery* Pilot Projects Recovery of Function* Stereotaxic Techniques Transplantation, Autologous Treatment Outcome Young Adult |
| Comments/Corrections | |
Comment In:
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Transl Res. 2010 Feb;155(2):55-6
[PMID:
20129484
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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