Document Detail

Open comparison of artemether and mefloquine in uncomplicated Plasmodium falciparum hyperparasitaemia in children.
MedLine Citation:
PMID:  8787366     Owner:  NLM     Status:  MEDLINE    
The efficacy of intramuscular artemether given for 5 days and a single oral dose of mefloquine, 25 mg/kg/body-weight, was evaluated in 84 children with uncomplicated Plasmodium falciparum hyperparasitaemia ( > 5% parasitized erythrocytes). Follow-up was for 14 days in the artemether group and 28 days in the mefloquine group. Artemether produced a significantly higher parasite reduction at 24 hours [mean 90.6 vs 63.3%, 95% confidence interval 10.7-43.9] and significantly shorter parasite clearance time [mean 38.4 vs 49.3 hours, 95% confidence interval 5.5-16.3] than mefloquine. Fever clearance times were similar, presumably because of the use of an antipyretic in both treatment groups. Cure rate was 98% with artemether on day 14 and 100% with mefloquine on day 28. One child in the artemether group who had recurrence of parasitaemia on day 14 responded promptly to mefloquine with clearance of parasitaemia and fever at 24 hours. Although both drugs were well tolerated, mefloquine produced more episodes of abdominal pain with or without diarrhoea and vomiting. These results suggest that both drugs are effective in uncomplicated Plasmodium falciparum hyperparasitaemia in children from an endemic area of south-west Nigeria.
A Sowunmi; A M Oduola; A O Ilesanmi; L A Salako
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of tropical paediatrics     Volume:  16     ISSN:  0272-4936     ISO Abbreviation:  Ann Trop Paediatr     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-26     Completed Date:  1996-09-26     Revised Date:  2009-08-18    
Medline Journal Info:
Nlm Unique ID:  8210625     Medline TA:  Ann Trop Paediatr     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  5-9     Citation Subset:  IM    
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
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MeSH Terms
Administration, Oral
Antimalarials / administration & dosage,  adverse effects,  therapeutic use*
Child, Preschool
Erythrocytes / parasitology
Follow-Up Studies
Injections, Intramuscular
Malaria, Falciparum / drug therapy*,  parasitology
Mefloquine / administration & dosage,  adverse effects,  therapeutic use*
Parasitemia / drug therapy*,  parasitology
Plasmodium falciparum / drug effects*,  isolation & purification
Retrospective Studies
Sesquiterpenes / administration & dosage,  adverse effects,  therapeutic use*
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/Sesquiterpenes; 0/artemether; 53230-10-7/Mefloquine

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