| Open comparison of artemether and mefloquine in uncomplicated Plasmodium falciparum hyperparasitaemia in children. | |
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MedLine Citation:
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PMID: 8787366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of intramuscular artemether given for 5 days and a single oral dose of mefloquine, 25 mg/kg/body-weight, was evaluated in 84 children with uncomplicated Plasmodium falciparum hyperparasitaemia ( > 5% parasitized erythrocytes). Follow-up was for 14 days in the artemether group and 28 days in the mefloquine group. Artemether produced a significantly higher parasite reduction at 24 hours [mean 90.6 vs 63.3%, 95% confidence interval 10.7-43.9] and significantly shorter parasite clearance time [mean 38.4 vs 49.3 hours, 95% confidence interval 5.5-16.3] than mefloquine. Fever clearance times were similar, presumably because of the use of an antipyretic in both treatment groups. Cure rate was 98% with artemether on day 14 and 100% with mefloquine on day 28. One child in the artemether group who had recurrence of parasitaemia on day 14 responded promptly to mefloquine with clearance of parasitaemia and fever at 24 hours. Although both drugs were well tolerated, mefloquine produced more episodes of abdominal pain with or without diarrhoea and vomiting. These results suggest that both drugs are effective in uncomplicated Plasmodium falciparum hyperparasitaemia in children from an endemic area of south-west Nigeria. |
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Authors:
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A Sowunmi; A M Oduola; A O Ilesanmi; L A Salako |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of tropical paediatrics Volume: 16 ISSN: 0272-4936 ISO Abbreviation: Ann Trop Paediatr Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-09-26 Completed Date: 1996-09-26 Revised Date: 2009-08-18 |
Medline Journal Info:
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Nlm Unique ID: 8210625 Medline TA: Ann Trop Paediatr Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 5-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Animals Antimalarials / administration & dosage, adverse effects, therapeutic use* Artemisinins* Child Child, Preschool Erythrocytes / parasitology Female Follow-Up Studies Humans Infant Injections, Intramuscular Malaria, Falciparum / drug therapy*, parasitology Male Mefloquine / administration & dosage, adverse effects, therapeutic use* Parasitemia / drug therapy*, parasitology Plasmodium falciparum / drug effects*, isolation & purification Retrospective Studies Sesquiterpenes / administration & dosage, adverse effects, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Artemisinins; 0/Sesquiterpenes; 0/artemether; 53230-10-7/Mefloquine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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