| Open access series of imaging studies: longitudinal MRI data in nondemented and demented older adults. | |
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MedLine Citation:
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PMID: 19929323 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Open Access Series of Imaging Studies is a series of neuroimaging data sets that are publicly available for study and analysis. The present MRI data set consists of a longitudinal collection of 150 subjects aged 60 to 96 years all acquired on the same scanner using identical sequences. Each subject was scanned on two or more visits, separated by at least 1 year for a total of 373 imaging sessions. Subjects were characterized using the Clinical Dementia Rating (CDR) as either nondemented or with very mild to mild Alzheimer's disease. Seventy-two of the subjects were characterized as nondemented throughout the study. Sixty-four of the included subjects were characterized as demented at the time of their initial visits and remained so for subsequent scans, including 51 individuals with CDR 0.5 similar level of impairment to individuals elsewhere considered to have "mild cognitive impairment." Another 14 subjects were characterized as nondemented at the time of their initial visit (CDR 0) and were subsequently characterized as demented at a later visit (CDR > 0). The subjects were all right-handed and include both men (n = 62) and women (n = 88). For each scanning session, three or four individual T1-weighted MRI scans were obtained. Multiple within-session acquisitions provide extremely high contrast to noise, making the data amenable to a wide range of analytic approaches including automated computational analysis. Automated calculation of whole-brain volume is presented to demonstrate use of the data for measuring differences associated with normal aging and Alzheimer's disease. |
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Authors:
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Daniel S Marcus; Anthony F Fotenos; John G Csernansky; John C Morris; Randy L Buckner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cognitive neuroscience Volume: 22 ISSN: 1530-8898 ISO Abbreviation: J Cogn Neurosci Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-11-30 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8910747 Medline TA: J Cogn Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 2677-84 Citation Subset: IM |
Affiliation:
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Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. dmarcus@wustl.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Brain / pathology* Brain Mapping Dementia / pathology* Female Humans Image Processing, Computer-Assisted Longitudinal Studies Magnetic Resonance Imaging* Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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P01 AG003991-19/AG/NIA NIH HHS; P01 AG003991-26/AG/NIA NIH HHS; P01 AG03991/AG/NIA NIH HHS; P20 MH071616/MH/NIMH NIH HHS; P30 NS048056-06/NS/NINDS NIH HHS; P50 AG005681-18/AG/NIA NIH HHS; P50 AG005681-20/AG/NIA NIH HHS; P50 AG05681/AG/NIA NIH HHS; P50 MH071616-050002/MH/NIMH NIH HHS; R01 AG021910/AG/NIA NIH HHS; R01 AG021910-03/AG/NIA NIH HHS; R01 AG021910-05/AG/NIA NIH HHS; R01 AG034556-01/AG/NIA NIH HHS; R01 AG034556-02/AG/NIA NIH HHS; R01 AG034556-03/AG/NIA NIH HHS; R01 EB009352-01A1/EB/NIBIB NIH HHS; R01 EB009352-03/EB/NIBIB NIH HHS; RR 16594/RR/NCRR NIH HHS; RR14075/RR/NCRR NIH HHS; U24 RR019701-04/RR/NCRR NIH HHS; U24 RR021382-05/RR/NCRR NIH HHS; U24 RR026057-01/RR/NCRR NIH HHS; //Howard Hughes Medical Institute |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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