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The Open Access Malaria Box: A Drug Discovery Catalyst for Neglected Diseases.
MedLine Citation:
PMID:  23798988     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Historically, one of the key problems in neglected disease drug discovery has been identifying new and interesting chemotypes. Phenotypic screening of the malaria parasite, Plasmodium falciparum has yielded almost 30,000 submicromolar hits in recent years. To make this collection more accessible, a collection of 400 chemotypes has been assembled, termed the Malaria Box. Half of these compounds were selected based on their drug-like properties and the others as molecular probes. These can now be requested as a pharmacological test set by malaria biologists, but importantly by groups working on related parasites, as part of a program to make both data and compounds readily available. In this paper, the analysis and selection methodology and characteristics of the compounds are described.
Authors:
Thomas Spangenberg; Jeremy N Burrows; Paul Kowalczyk; Simon McDonald; Timothy N C Wells; Paul Willis
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-17
Journal Detail:
Title:  PloS one     Volume:  8     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2013  
Date Detail:
Created Date:  2013-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  -    
Other Details:
Languages:  ENG     Pagination:  e62906     Citation Subset:  -    
Affiliation:
Medicines for Malaria Venture (MMV), Geneva, Switzerland.
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