Document Detail

Oophorectomy, menopause, estrogen, and cognitive aging: the timing hypothesis.
MedLine Citation:
PMID:  20197698     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The concept of neuroprotective effects of estrogen in women remains controversial.
OBJECTIVE: To explore the timing hypothesis in relation to cognitive aging and dementia.
METHODS: We reviewed existing literature, conducted some reanalyses, and combined results graphically.
RESULTS: Current evidence suggests that estrogen may have either protective effects or harmful effects on the brain depending on age, type of menopause (natural versus surgical), or stage of menopause. The comparison of women with ovarian conservation versus women who underwent bilateral oophorectomy provided evidence for a sizeable neuroprotective effect of estrogen in women in the premenopausal years (most commonly before age 50 years). Several case-control studies and cohort studies also showed a neuroprotective effect in women who received estrogen treatment in the early postmenopausal phase (most commonly at ages 50-60 years). However, recent clinical trials showed that women who initiated estrogen treatment in the late postmenopausal phase (ages 65-79 years) experienced an increased risk of dementia and cognitive decline.
CONCLUSION: The neuroprotective effects of estrogen depend on age, type of menopause, and stage of menopause (timing hypothesis).
Walter A Rocca; Brandon R Grossardt; Lynne T Shuster
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-03-03
Journal Detail:
Title:  Neuro-degenerative diseases     Volume:  7     ISSN:  1660-2862     ISO Abbreviation:  Neurodegener Dis     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-14     Completed Date:  2010-07-21     Revised Date:  2013-10-30    
Medline Journal Info:
Nlm Unique ID:  101189034     Medline TA:  Neurodegener Dis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 S. Karger AG, Basel.
Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
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MeSH Terms
Aging / drug effects*,  pathology,  psychology
Cognition Disorders / drug therapy*,  etiology
Estrogens / therapeutic use*
Menopause / drug effects*,  psychology
Neuroprotective Agents / therapeutic use*
Ovariectomy / adverse effects*
Women's Health
Grant Support
Reg. No./Substance:
0/Estrogens; 0/Neuroprotective Agents

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