Document Detail

Oocyte-specific genes affect folliculogenesis, fertilization, and early development.
MedLine Citation:
PMID:  17594605     Owner:  NLM     Status:  MEDLINE    
Although cell-autonomous genetic programs pursued by germ and somatic cells are of critical import, intimate interplays between the two cell types are also essential for normal development of the female gonad. Recent studies demonstrate that oocytes play active roles in coordinating the growth and differentiation of somatic cells during folliculogenesis and affect successful outcomes at fertilization and early development. Mouse transgenesis has been particularly useful in defining germ-cell specific genes and their roles in folliculogenesis (e.g., DAZLA, FIGLA, NOBOX, SOHLH1, YBX2, CPEB1, GDF9), fertilization (e.g., ZP1, ZP2, ZP3), and preimplantation embryonic development (e.g., NPM2, ZAR1, NALP5, DPPA3). Continued identification of novel oocyte-specific genes and the annotation of their functions will provide additional insight into the genetic pathways regulating ovarian development. The knowledge gained from mouse models will no doubt benefit the understanding of human biology and treatment of reproductive failure.
Ping Zheng; Jurrien Dean
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Review    
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  25     ISSN:  1526-8004     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-27     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  243-51     Citation Subset:  IM    
Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA.
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MeSH Terms
Egg Proteins / genetics*,  metabolism
Embryonic Development / genetics*
Fertilization / genetics*
Gene Expression Profiling
Gene Expression Regulation, Developmental*
Genetic Predisposition to Disease
Infertility, Female / genetics
Mice, Transgenic
Oocytes / physiology*
Oogenesis / genetics*
Reg. No./Substance:
0/Egg Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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