Document Detail


Oocyte-somatic cell communication and microRNA function in the ovary.
MedLine Citation:
PMID:  20362967     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
An enormous amount of knowledge about the ovary has been generated over the last two decades, due in part to the development of strategies to genetically manipulate the mouse using embryonic stem cell technology. Our group and others have identified multiple factors that are important and essential at all stages of ovarian folliculogenesis from formation of the primordial factor to ovulation. It is obvious that an oocyte, the key cargo of the ovary, and the surrounding granulosa cells, the support cells of the follicle, entertain a dialog that is key for granulosa growth and differentiation and oocyte growth, maturation, and fertilization. In addition to the involvement of genes in these processes, small non-coding RNAs including microRNAs and siRNAs have been implicated as key regulators, especially in the oocyte. These studies have direct implications for human fertility control in the assisted reproductive technology (ART) laboratory.
Authors:
S M Hawkins; M M Matzuk
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-04-02
Journal Detail:
Title:  Annales d'endocrinologie     Volume:  71     ISSN:  0003-4266     ISO Abbreviation:  Ann. Endocrinol. (Paris)     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-10     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0116744     Medline TA:  Ann Endocrinol (Paris)     Country:  France    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Masson SAS. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication
Embryonic Stem Cells / physiology
Female
Fertility / physiology
Fertilization
Granulosa Cells / cytology,  physiology
Homeostasis
Humans
Infertility, Female / physiopathology
Mice
MicroRNAs / genetics*
Oocytes / physiology*
Ovary / physiology*
Ovulation / physiology
RNA, Small Interfering / genetics
Reproductive Techniques, Assisted
Grant Support
ID/Acronym/Agency:
5K12HD050128/HD/NICHD NIH HHS; K12 HD050128-05/HD/NICHD NIH HHS; R01 CA060651/CA/NCI NIH HHS; R01 CA060651-18/CA/NCI NIH HHS; R01 HD032067/HD/NICHD NIH HHS; R01 HD032067-08/HD/NICHD NIH HHS; R01CA60651/CA/NCI NIH HHS; R01HD32067/HD/NICHD NIH HHS; R37 HD033438/HD/NICHD NIH HHS; R37 HD033438-15/HD/NICHD NIH HHS; R37HD33438/HD/NICHD NIH HHS; U54 HD007495/HD/NICHD NIH HHS; U54 HD007495-34/HD/NICHD NIH HHS; U54HD07495/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Small Interfering
Comments/Corrections

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