| Oocyte regulation of anti-Müllerian hormone expression in granulosa cells during ovarian follicle development in mice. | |
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MedLine Citation:
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PMID: 14729489 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the ovarian follicle, anti-Müllerian hormone (Amh) mRNA is expressed in granulosa cells from primary to preovulatory stages but becomes restricted to cumulus cells following antrum formation. Anti-Müllerian hormone regulates follicle development by attenuating the effects of follicle stimulating hormone on follicle growth and inhibiting primordial follicle recruitment. To examine the role of the oocyte in regulating granulosa cell Amh expression in the mouse, isolated oocytes and granulosa cells were co-cultured and Amh mRNA levels were analysed by real-time RT-PCR. Expression in freshly isolated granulosa cells increased with preantral follicle development but was low in the cumulus and virtually absent in the mural granulosa cells of preovulatory follicles. When preantral granulosa cells were co-cultured with oocytes from early preantral, late preantral or preovulatory follicles, and when oocytes from preovulatory follicles were co-cultured with cumulus granulosa cells, Amh expression was increased at least 2-fold compared with granulosa cells cultured alone. With oocytes from preantral but not preovulatory follicles, this was a short-range effect only observed with granulosa cells in close apposition to oocytes. We conclude that stage-specific oocyte regulation of Amh expression may play a role in intra- and inter-follicular coordination of follicle development. |
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Authors:
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Nicholas A Salmon; Alan H Handyside; Ieuan M Joyce |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental biology Volume: 266 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-19 Completed Date: 2004-03-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 201-8 Citation Subset: IM |
Affiliation:
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School of Biology, University of Leeds, Leeds LS2 9JT, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Mullerian Hormone Base Sequence DNA Primers Female Glycoproteins / genetics* Granulosa Cells / metabolism* Mice Oocytes / physiology* RNA, Messenger / genetics Testicular Hormones / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Glycoproteins; 0/RNA, Messenger; 0/Testicular Hormones; 80497-65-0/Anti-Mullerian Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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