| Oocyte maturation, Mos and cyclins--a matter of synthesis: two functionally redundant ways to induce meiotic maturation. | |
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MedLine Citation:
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PMID: 16760654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of an immature oocyte into a fertilizable gamete is a process known as meiotic maturation. In vertebrates, it corresponds to the transition from the prophase arrest of the first meiotic division (usually considered as a late G(2) phase) to the metaphase arrest of the second meiotic division. This transition is controlled by modulating the activity of the cyclin B-Cdc2 complex, MPF (M-phase promoting factor), the universal regulator of the G(2)/M transition. Meiotic maturation of frog oocytes is triggered by steroid hormones through a rapid, necessary and sufficient suppression of PKA and requires ongoing protein synthesis. A long-standing question has been to identify key protein(s) required to trigger the activation of MPF in response to the hormonal signal. Here we will discuss data supporting the view that steroids bring about meiotic maturation through functionally redundant pathways involving synthesis of Mos or of cyclin proteins, reinforcing the robustness of the system. |
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Authors:
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Olivier Haccard; Catherine Jessus |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2006-06-01 |
Journal Detail:
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Title: Cell cycle (Georgetown, Tex.) Volume: 5 ISSN: 1551-4005 ISO Abbreviation: Cell Cycle Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-06-15 Completed Date: 2006-08-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 101137841 Medline TA: Cell Cycle Country: United States |
Other Details:
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Languages: eng Pagination: 1152-9 Citation Subset: IM |
Affiliation:
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Laboratoire de Biologie du Développement, Equipe Biologie de l'Ovocyte UMR CNRS 7622, Université Pierre et Marie Curie, Paris, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amphibian Proteins Amphibians Animals Cyclins / physiology* Germ Cells / cytology Meiosis* Oocytes / physiology* Proto-Oncogene Proteins c-mos / physiology* Signal Transduction Steroids / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Amphibian Proteins; 0/Cyclins; 0/Steroids; EC 2.7.11.1/Proto-Oncogene Proteins c-mos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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