Document Detail

Oocyte donation: insights into implantation.
MedLine Citation:
PMID:  9935110     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To ascertain whether obstetric, gynecologic, or congenital variables affect implantation efficiency or eventual delivery in donor oocyte recipients. DESIGN: Clinical study. SETTING: Academic tertiary care infertility clinic. PATIENT(S): A total of 370 recipients. INTERVENTION(S): Fresh ET following oocyte donation in a hormone replacement cycle. MAIN OUTCOME MEASURE(S): Regression analyses were performed to detect any statistically significant difference in the pregnancy rate (PR), delivery rate, miscarriage rate, or implantation rate associated with different obstetric, gynecologic, and congenital independent variables while accounting for the age of the recipient in each analysis. RESULT(S): For all recipients, a clinical PR per transfer of 58.9% was achieved, with an implantation rate of 30%. A significant decline in the implantation rate was noted in relation to increasing age of the recipient. A history of tubal disease was associated with a significantly lower implantation rate and a significantly lower ongoing and delivered PR. Asherman's syndrome, despite surgical correction, appeared to negatively affect the ongoing and delivered PR. CONCLUSION(S): With the exceptions of recipient age and a history of tubal disease, all other uterine factors studied did not appear to influence the implantation potential of an embryo resulting from oocyte donation. A history of tubal disease had a distinctly negative effect on implantation efficiency and delivery potential for a given recipient. This finding highlights the need to identify the mechanisms underlying the negative effect of tubal disease so that donor oocyte recipients and all other patients with this cause of infertility can benefit from directed therapy.
M Moomjy; I Cholst; R Mangieri; Z Rosenwaks
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  71     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-02-23     Completed Date:  1999-02-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-21     Citation Subset:  IM    
Center For Reproductive Medicine and Infertility, Department of Obstetrics and Gynecology, The New York Hospital-Cornell Medical Center, New York 10021, USA.
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MeSH Terms
Age Factors
Embryo Implantation / physiology*
Embryo Transfer
Genital Diseases, Female / congenital,  physiopathology
Oocyte Donation*
Pregnancy Outcome
Retrospective Studies
Treatment Outcome
Comment In:
Fertil Steril. 1999 Jul;72(1):185-7   [PMID:  10428177 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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