| Oocyte control of ovarian follicular development and function in mammals. | |
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MedLine Citation:
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PMID: 11732978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new perspective on ovarian follicular development has emerged over the last decade. Whereas the oocyte was previously considered only a passive recipient of developmental signals from oocyte-associated granulosa cells, it is now clear that communication between oocytes and granulosa cells is bidirectional. A complex interplay of regulatory factors governs the development of both types of cell. This interplay is essential not only for oocyte development but also for follicular development, beginning with the initial assembly of the primordial follicle and continuing throughout ovulation. The existence of an oocyte-granulosa cell regulatory loop, essential for normal follicular differentiation as well as for the production of an oocyte competent to undergo fertilization and embryogenesis, is proposed. Although gonadotrophins are essential for driving the differentiation of granulosa cell phenotypes, within its sphere of influence, the oocyte is probably the dominant factor determining the direction of differentiation and the function of the granulosa cells associated with it. |
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Authors:
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J J Eppig |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: 122 ISSN: 1470-1626 ISO Abbreviation: Reproduction Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-04 Completed Date: 2002-06-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: England |
Other Details:
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Languages: eng Pagination: 829-38 Citation Subset: IM |
Affiliation:
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The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. jje@jax.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Cell Division / physiology Female Mammals / physiology* Oocytes / physiology* Ovarian Follicle / physiology* Ovulation / physiology* Prostaglandin-Endoperoxide Synthases / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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HD21970/HD/NICHD NIH HHS; HD23839/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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EC 1.14.99.1/Prostaglandin-Endoperoxide Synthases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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