Document Detail


Onyx in an experimental aneurysm model: histological and angiographic results.
MedLine Citation:
PMID:  18590435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECT: The use of liquid embolic agents for endovascular treatment of cerebral aneurysms is evolving. The authors' aim was to evaluate the use of Onyx HD-500 in an experimental aneurysm model and to obtain histological and angiographic long-term results. METHODS: Ten aneurysms were created using an elastase model in rabbits. The aneurysms were embolized using Onyx in combination with an inflated balloon. One animal died 1 day after embolization. The animals were divided into 2 different groups. The animals in the first group (4 rabbits) were killed at 3 months and those in the second group (5 rabbits) were killed at 6 months after embolization. A venous control angiogram was obtained, and the aneurysms were examined histologically. RESULTS: In both groups control angiograms demonstrated that all aneurysms were completely occluded. There were no signs of recanalization. Migration of Onyx was seen in 4 animals, leading to the death of 1. Histological examination not only proved the aneurysms to be occluded but also demonstrated a thin layer of endothelium at the neck of the aneurysm. The histological result was identical in both groups. CONCLUSIONS: This is the first study reporting the formation of a neointima over the neck of aneurysms embolized with Onyx in a rabbit model. Although the technique is challenging and migration of the liquid embolic agent cannot always be prevented, Onyx has a great potential to achieve a durable occlusion of aneurysms.
Authors:
Tobias Struffert; Christian Roth; Bernd Romeike; Iris O Grunwald; Wolfgang Reith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  109     ISSN:  0022-3085     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-01     Completed Date:  2008-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-82     Citation Subset:  AIM; IM    
Affiliation:
Department of Neuroradiology, University Hospital of Erlangen, Erlangen, Germany. tobias.struffert@nrad.imed.uni-erlangen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Balloon Dilatation*
Cerebral Angiography
Dimethyl Sulfoxide*
Disease Models, Animal
Embolization, Therapeutic / methods*
Intracranial Aneurysm / pathology,  radiography,  therapy*
Pancreatic Elastase
Polyvinyls*
Rabbits
Treatment Outcome
Chemical
Reg. No./Substance:
0/Onyx HD 500; 0/Polyvinyls; 67-68-5/Dimethyl Sulfoxide; EC 3.4.21.36/Pancreatic Elastase

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