Document Detail


Onychomycosis caused by Fusarium sp in Sri Lanka: prevalence, clinical features and response to itraconazole pulse therapy in six cases.
MedLine Citation:
PMID:  19160539     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aims of our study were to ascertain the proportion of Fusarium onychomycosis among patients with suspected onychomycosis, to record clinical features and to assess the efficacy of itraconazole pulse therapy in treatment. METHODS: Six patients with positive isolates of Fusarium sp were treated in an open, prospective manner with itraconazole: two pulses for fingernails and three pulses for toenails. Significant growth of Fusarium sp was considered when both microscopy of direct mounts in KOH and culture were positive for mold. Efficacy parameters were mycological cure and clinical cure. Mycological cure was negative direct microscopy (KOH) and culture. Clinical cure was complete absence of signs of onychomycosis. RESULTS: Prevalence of Fusarium onychomycosis was 6.25% (8/128). Three women and three men were studied. All had bilateral big toenails involved which were of the distal and lateral onychomycosis. Three of them had associated fingernail onychomycosis with periungual inflammation. All our patients were immunocompetent. At month 12 from the start of treatment, mycological cure was 100% while only three out of five patients showed normal nail growth and clinical cure. There were no significant clinical or laboratory adverse effects. CONCLUSIONS: Our data reconfirmed that Fusarium nail infections are difficult to eradicate. Since the therapeutic reservoir in toenails is 11 months, these patients should be followed up for a total of 12 months before coming to the final conclusion.
Authors:
Ranthilaka R Ranawaka; Nelun de Silva; Ramya W Ragunathan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  19     ISSN:  0954-6634     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2008  
Date Detail:
Created Date:  2009-01-22     Completed Date:  2009-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  England    
Other Details:
Languages:  eng     Pagination:  308-12     Citation Subset:  IM    
Affiliation:
Teaching Hospital Karapitiya, Galle, Sri Lanka. ranthilaka37@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Antifungal Agents / therapeutic use*
Cohort Studies
Female
Foot Dermatoses / drug therapy,  epidemiology,  microbiology*
Fusarium*
Humans
Itraconazole / therapeutic use*
Male
Middle Aged
Onychomycosis / drug therapy,  epidemiology,  microbiology*
Prevalence
Sri Lanka
Chemical
Reg. No./Substance:
0/Antifungal Agents; 84625-61-6/Itraconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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