Document Detail


Onychomycosis caused by Fusarium sp in Sri Lanka: Prevalence, clinical features and response to itraconazole pulse therapy in six cases.
MedLine Citation:
PMID:  18608716     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objectives: The aims of our study were to ascertain the proportion of Fusarium onychomycosis among patients with suspected onychomycosis, to record clinical features and to assess the efficacy of itraconazole pulse therapy in treatment. Methods: Six patients with positive isolates of Fusarium sp were treated in an open, prospective manner with itraconazole: two pulses for fingernails and three pulses for toenails. Significant growth of Fusarium sp was considered when both microscopy of direct mounts in KOH and culture were positive for mold. Efficacy parameters were mycological cure and clinical cure. Mycological cure was negative direct microscopy (KOH) and culture. Clinical cure was complete absence of signs of onychomycosis. Results: Prevalence of Fusarium onychomycosis was 6.25% (8/128). Three women and three men were studied. All had bilateral big toenails involved which were of the distal and lateral onychomycosis. Three of them had associated fingernail onychomycosis with periungual inflammation. All our patients were immunocompetent. At month 12 from the start of treatment, mycological cure was 100% while only three out of five patients showed normal nail growth and clinical cure. There were no significant clinical or laboratory adverse effects. Conclusions: Our data reconfirmed that Fusarium nail infections are difficult to eradicate. Since the therapeutic reservoir in toenails is 11 months, these patients should be followed up for a total of 12 months before coming to the final conclusion.
Authors:
Ranthilaka R Ranawaka; Nelun De Silva; Ramya W Ragunathan
Related Documents :
20920216 - Potential threat of malaria epidemics in a low transmission area, as exemplified by sã...
19654536 - Five-year follow-up on the effect of oral acyclovir after penetrating keratoplasty for ...
10949326 - Progress and problems in achieving the united states national target for completion of ...
12425486 - Eleven years of experience with dialysis associated tuberculosis.
23744836 - A new supporting material for fascia grafting during myringoplasty: polyglycolic acid s...
3093776 - Blood groups and malignant melanoma.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-4-29
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-5     Citation Subset:  -    
Affiliation:
Teaching Hospital Karapitiya, Galle, Sri Lanka.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Clinical investigation of acitretin in children with severe inherited keratinization disorders in Ch...
Next Document:  Successful treatment of perforating granuloma annulare with 0.1% tacrolimus ointment.