| Onyalai--the possible involvement of a mycotoxin produced by Phoma sorghina in the aetiology. | |
| | |
MedLine Citation:
|
PMID: 1080886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A number of species of fungi were isolated from millet (Pennisetum typhoides Staph and Hubb) and grain sorghum (Sorghum vulgare Pers) obtained from the households of patients suffering from onyalai. Several proved to be toxic to rats and chickens, including Phoma sorghina (Sacc.) which was the predominating fungus. Cultures of P. sorghina grown on maize and wheat were added to standard rations at concentrations of 5-30%. When fed to day-old New Hampshire chickens, the majority died within 4 days, exhibiting traces of blood on the beak and the cloaca. Rats given 10% or more of the mouldered material in the diet developed thrombocytopenia after 14 days which was followed by haematuria, epistaxis, melaena, and death. Pathological, including histological examination, revealed extensive damage to the fascular system which resulted in widespread haemorrhages. |
| | |
Authors:
|
C J Rabie; S J Van Rensburg; J J Van Der Watt; A Lübben |
Related Documents
:
|
13866126 - Rapid lethal effect in rats of a third component found upon fractionating the toxin of ... 4026916 - Acute and subacute toxicity of 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(o-difluoromethoxyp... 915446 - Consumptive coagulopathy as biochemical mechanism in oxygen toxicity and its enhancemen... 20420666 - Aryl hydrocarbon receptor (ahr)-regulated transcriptomic changes in rats sensitive or r... 6636826 - Formation and disposition of n-hydroxylated metabolites of aniline and nitrobenzene by ... 7469486 - Effects in the rat of inhaling pvc dust at the nuisance dust level (10 mg/m3). |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 49 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 1975 Sep |
Date Detail:
|
Created Date: 1975-12-11 Completed Date: 1975-12-11 Revised Date: 2004-09-28 |
Medline Journal Info:
|
Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: SOUTH AFRICA |
Other Details:
|
Languages: eng Pagination: 1647-50 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cereals* Chickens Food Contamination Food Microbiology* Male Mitosporic Fungi* / isolation & purification Mycotoxins / toxicity* Oral Hemorrhage / etiology Panicum* Purpura, Thrombocytopenic / etiology* Rats |
| Chemical | |
Reg. No./Substance:
|
0/Mycotoxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Myelopoiesis--a kinetic approach
Next Document: The radiological presentation of pulmonary tuberculosis in children.