Document Detail

Ontogeny of susceptibility to experimental febrile seizures in rats.
MedLine Citation:
PMID:  3371558     Owner:  NLM     Status:  MEDLINE    
Two experiments were conducted using microwave hyperthermia (MHT) to induce seizures among limited numbers of Long-Evans rat pups. The MHT model of febrile seizures eliminates several methodological complications inherent in previous animal models of the disorder. In Experiment 1, rat pups were rendered hyperthermic with MHT or were sham-irradiated on Days 11, 13, 15 or 17 postpartum. The results indicate a statistically significant decline in seizure susceptibility with age. In Experiment 2, rats were subjected to either single or multiple hyperthermic episodes on Days 11, 13, 15, or 17 postpartum. The results indicate an increase in susceptibility to seizures attributable to prior seizure history. In both experiments, seizures were induced with increases in rectal temperature of 1 to 3 degrees C. The results parallel many clinical features of febrile seizures and argue the efficacy of the MHT model.
D L Hjeresen; J Diaz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental psychobiology     Volume:  21     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-06-24     Completed Date:  1988-06-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  261-75     Citation Subset:  IM    
Biophysics/Neurobiology Group, Los Alamos National Laboratory, NM 87545.
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MeSH Terms
Animals, Newborn
Behavior, Animal / physiology
Brain / physiopathology
Disease Models, Animal
Rats, Inbred Strains
Seizures, Febrile / physiopathology*

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