| Ontogeny of susceptibility to experimental febrile seizures in rats. | |
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MedLine Citation:
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PMID: 3371558 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two experiments were conducted using microwave hyperthermia (MHT) to induce seizures among limited numbers of Long-Evans rat pups. The MHT model of febrile seizures eliminates several methodological complications inherent in previous animal models of the disorder. In Experiment 1, rat pups were rendered hyperthermic with MHT or were sham-irradiated on Days 11, 13, 15 or 17 postpartum. The results indicate a statistically significant decline in seizure susceptibility with age. In Experiment 2, rats were subjected to either single or multiple hyperthermic episodes on Days 11, 13, 15, or 17 postpartum. The results indicate an increase in susceptibility to seizures attributable to prior seizure history. In both experiments, seizures were induced with increases in rectal temperature of 1 to 3 degrees C. The results parallel many clinical features of febrile seizures and argue the efficacy of the MHT model. |
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Authors:
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D L Hjeresen; J Diaz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Developmental psychobiology Volume: 21 ISSN: 0012-1630 ISO Abbreviation: Dev Psychobiol Publication Date: 1988 Apr |
Date Detail:
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Created Date: 1988-06-24 Completed Date: 1988-06-24 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0164074 Medline TA: Dev Psychobiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 261-75 Citation Subset: IM |
Affiliation:
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Biophysics/Neurobiology Group, Los Alamos National Laboratory, NM 87545. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Behavior, Animal / physiology Brain / physiopathology Disease Models, Animal Female Male Rats Rats, Inbred Strains Recurrence Seizures, Febrile / physiopathology* |
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