Document Detail


Ontogeny of somatostatin binding sites in the rabbit small intestinal epithelial tract.
MedLine Citation:
PMID:  2897463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ontogenic patterns of somatostatin content and its binding sites were studied in small intestine in the developing rabbit from birth until the adult stage. A peak of somatostatin concentration was observed immediately after birth (day 0) and at day 10 in duodenum and jejunum, followed by a decrease at day 15 and a new and gradual augment thereafter. Ileal somatostatin concentrations decreased after birth up to day 15 and then increased progressively with age until the adult period. The somatostatin binding capacity in cytosol of the mucosal layer of duodenum, jejunum and ileum decreased from birth until 10 days and increased thereafter up to the adult period. However, no age differences in dissociation constants were observed. Interestingly, there was an apparent lack of high-affinity sites immediately after birth (day 0) whereas two classes of binding sites were seen thereafter. These results suggest that somatostatin may be involved in the functional and anatomical development of the small intestine during the neonatal period.
Authors:
M P López-Ruiz; E Arilla
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of receptor research     Volume:  7     ISSN:  0197-5110     ISO Abbreviation:  J. Recept. Res.     Publication Date:  1987  
Date Detail:
Created Date:  1988-07-11     Completed Date:  1988-07-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008358     Medline TA:  J Recept Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  829-43     Citation Subset:  IM    
Affiliation:
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá de Henares, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Binding Sites
Binding, Competitive
Duodenum / metabolism
Epithelium / metabolism
Ileum / metabolism
Intestinal Mucosa / metabolism
Intestine, Small / analysis,  metabolism*
Jejunum / metabolism
Rabbits
Radioimmunoassay
Somatostatin / metabolism*
Chemical
Reg. No./Substance:
51110-01-1/Somatostatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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