Document Detail


Ontogeny of the skin and the transition from scar-free to scarring phenotype during wound healing in the pouch young of a marsupial, Monodelphis domestica.
MedLine Citation:
PMID:  7750642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The marsupial Monodelphis domestica provides a versatile model for the study of "fetal" wound healing. The pouch young of this species have been used to perform a systematic histological study of wound healing and skin development throughout pouch life; from Pouch Day 0 to Pouch Day 30 with comparisons drawn against adults. We have demonstrated that pouch young heal without macroscopic scars if wounded before Pouch Day 9 and that a transition into a scarring healing phenotype occurs around the ninth pouch day. The inflammatory reaction of wounds and aspects of skin differentiation such as dermal collagen organisation, adipose layer development, hair follicle growth, and epithelial maturation have been documented using simple ranking scales to highlight trends through pouch life. Inflammation was noted to become prominent after Pouch Day 9. There was also a general temporal correlation between the other aspects of differentiation and the transition into a scarring phenotype. It is concluded that although fetal wounds may have different cytokine profiles due to the differences of inflammatory reaction compared to adults, other aspects of skin development play a role in determining the healing phenotype.
Authors:
J R Armstrong; M W Ferguson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental biology     Volume:  169     ISSN:  0012-1606     ISO Abbreviation:  Dev. Biol.     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-16     Completed Date:  1995-06-16     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-60     Citation Subset:  IM    
Affiliation:
Cells, Immunology and Development Division, School of Biological Sciences, University of Manchester, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Aging / physiology*
Animals
Cicatrix / etiology*
Epithelium / growth & development
Hair / growth & development
Inflammation
Muscles / pathology
Opossums / physiology*
Phenotype
Skin / growth & development*,  injuries,  pathology
Wound Healing / physiology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust

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