Document Detail

Ontogeny of salivary epidermal growth factor and necrotizing enterocolitis.
MedLine Citation:
PMID:  17382110     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the ontogeny of salivary epidermal growth factor (sEGF) in premature infants and to determine the relation of sEGF to the development of necrotizing enterocolitis (NEC). STUDY DESIGN: Salivary EGF was prospectively measured in 327 infants with gestational ages from 23 weeks to term. Infants of < or = 32 weeks' gestation (n = 261) were followed with weekly sEGF measurements through 3 weeks of life. Multivariable regression analyses were used to determine variables significantly related to sEGF levels and to identify predictors of NEC. RESULTS: Over the first 3 weeks of life, sEGF increased across gestational age and postnatal age categories. In multivariable models, gestational age was a significant predictor of sEGF levels (P < .009). In a cohort of 27 infants who had NEC, gestational age, race, and changes in sEGF levels between weeks of life 1 and 2 were predictive of the development of NEC. These infants had lower sEGF at week 1 and greater increases from week 1 to week 2 compared with infants without NEC. CONCLUSIONS: There is a positive relation between sEGF levels and gestational age. Patterns of sEGF levels over the first 2 weeks of life were significantly related to development of NEC in very low birth weight infants.
Barbara B Warner; Ann Ladd Ryan; Kimberly Seeger; Anthony C Leonard; Christopher R Erwin; Brad W Warner
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  150     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-26     Completed Date:  2007-04-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  358-63     Citation Subset:  AIM; IM    
Division of Neonatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
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MeSH Terms
Age Factors
Anti-Bacterial Agents / therapeutic use
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Apgar Score
Cohort Studies
Continental Population Groups / statistics & numerical data
Enterocolitis, Necrotizing / epidemiology,  metabolism*
Epidermal Growth Factor / metabolism*
Gestational Age
Indomethacin / therapeutic use
Infant Formula
Infant, Newborn
Infant, Premature / metabolism*
Milk, Human
Multivariate Analysis
Odds Ratio
Ohio / epidemiology
Prospective Studies
Regression Analysis
Risk Factors
Saliva / metabolism*
Grant Support
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin; 62229-50-9/Epidermal Growth Factor
Comment In:
J Pediatr. 2007 Apr;150(4):329-30   [PMID:  17382103 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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