| Ontogeny of the pig hypothalamic neurosecretory system with particular reference to the distribution of neurophysin. | |
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MedLine Citation:
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PMID: 1203966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The immunoperoxidase cytochemical reaction was applied to the localization of neurophysin-containing elements in the fetal and adult pig hypothalamus. In the 60 day fetal pig, cells of the supraoptic nucleus (SON) were the only structues in the hypothalamus in which neurophysin was detected. However, by 87 days the cell bodies in both the SON and paraventricular nucleus (PVN) contained neurophysin-like material. The distribution of immunoreactive material in the 111 day fetal animal was similar to that found in the adult pig. In transverse section of the mature pig the SON exists in two discrete components; an antero-lateral group of cells connected by scattered cells to a smaller postero-medial group. Anteriorly, the PVN appears as a line of cells bordering the third ventricle but as we proceed posteriorly the dorsal aspect expands laterally to give a wedge-shaped group of cells. In mid-sagittal sections, the cells of the PVN are distributed over a wide area of the anterior hypothalamus in a triangular profile. The borders between the SON and PVN became more difficult to define in medial sections than in lateral sections. Continuous gradient polyacrylamide gel electrophoresis was carried out on the neural lobe extracts from fetal, newborn and adult pigs. Proteins with an electrophoretic mobility similar to that of porcine neurophysins-I, -II and -III were present in the newborn and 98 day fetal pig. It is concluded that material immunoreactive with anti-neurophysin serum is present in the hypothalamus of the 60 day fetal pig. Furthermore, at late fetal development and during the postnatal period it is tentatively suggested that the neurophysin present in the pituitaries of these animals is chemically identical with that of adult neurophysin. |
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Authors:
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H K Ellis; W B Watkins |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell and tissue research Volume: 164 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 1975 Dec |
Date Detail:
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Created Date: 1976-03-11 Completed Date: 1976-03-11 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 543-57 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Electrophoresis, Polyacrylamide Gel Horseradish Peroxidase / immunology Hypothalamo-Hypophyseal System / analysis, embryology* Neurophysins / analysis* Paraventricular Hypothalamic Nucleus / analysis Pituitary Gland, Posterior / analysis Supraoptic Nucleus / analysis Swine / embryology* |
| Chemical | |
Reg. No./Substance:
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0/Neurophysins; EC 1.11.1.-/Horseradish Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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