| Ontogeny of phenylalanine (endogenous cholecystokinin) induced modulation of food intake in normal and undernourished rats. | |
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MedLine Citation:
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PMID: 1862220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The development of endogenous cholecystokinin (CCK) effects on food intake was studied in normal and undernourished growing rats of postnatal day 1-22. 2. Food intake was estimated by recording the gain in body weight before weaning. 3. l-phenylalanine, a potent stimulant of endogenous CCK release, suppressed 30 min food intake in normally nourished pups of day 7-15 or more but not of day 1-6 rats. 4. However, l-phenylalanine did not affect 24 hr gain in body weight day 1-6 or more, rat pups. 5. l-phenylalanine neither suppressed 30 min food intake nor affected 24 hr body weight in day 16-19 or 20-22 undernourished rat pups. 6. The study suggests that the endogenous CCK satiety effects appear early in the second week of postnatal life in normally nourished rats, whereas in undernourished rat pups it does not appear till day 20-22. |
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Authors:
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R Mathur; S K Manchanda |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Progress in neuro-psychopharmacology & biological psychiatry Volume: 15 ISSN: 0278-5846 ISO Abbreviation: Prog. Neuropsychopharmacol. Biol. Psychiatry Publication Date: 1991 |
Date Detail:
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Created Date: 1991-08-30 Completed Date: 1991-08-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8211617 Medline TA: Prog Neuropsychopharmacol Biol Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 405-13 Citation Subset: IM |
Affiliation:
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Department of Physiology, All India Institute of Medical Sciences, New Delhi. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Cholecystokinin / physiology* Diet Eating / drug effects, physiology* Male Nutrition Disorders / physiopathology* Nutritional Status Phenylalanine / pharmacology* Rats Satiety Response / drug effects |
| Chemical | |
Reg. No./Substance:
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63-91-2/Phenylalanine; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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