Document Detail

Ontogeny of phenylalanine (endogenous cholecystokinin) induced modulation of food intake in normal and undernourished rats.
MedLine Citation:
PMID:  1862220     Owner:  NLM     Status:  MEDLINE    
1. The development of endogenous cholecystokinin (CCK) effects on food intake was studied in normal and undernourished growing rats of postnatal day 1-22. 2. Food intake was estimated by recording the gain in body weight before weaning. 3. l-phenylalanine, a potent stimulant of endogenous CCK release, suppressed 30 min food intake in normally nourished pups of day 7-15 or more but not of day 1-6 rats. 4. However, l-phenylalanine did not affect 24 hr gain in body weight day 1-6 or more, rat pups. 5. l-phenylalanine neither suppressed 30 min food intake nor affected 24 hr body weight in day 16-19 or 20-22 undernourished rat pups. 6. The study suggests that the endogenous CCK satiety effects appear early in the second week of postnatal life in normally nourished rats, whereas in undernourished rat pups it does not appear till day 20-22.
R Mathur; S K Manchanda
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  15     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1991  
Date Detail:
Created Date:  1991-08-30     Completed Date:  1991-08-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  405-13     Citation Subset:  IM    
Department of Physiology, All India Institute of Medical Sciences, New Delhi.
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MeSH Terms
Body Weight / drug effects
Cholecystokinin / physiology*
Eating / drug effects,  physiology*
Nutrition Disorders / physiopathology*
Nutritional Status
Phenylalanine / pharmacology*
Satiety Response / drug effects
Reg. No./Substance:
63-91-2/Phenylalanine; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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