Document Detail


Ontogeny of methionine utilization and splanchnic uptake in critically ill children.
MedLine Citation:
PMID:  19724018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the rates of methionine splanchnic uptake and utilization in critically ill pediatric patients we used two kinetic models: the plasma methionine enrichment and the "intracellular" homocysteine enrichment. Twenty four patients, eight infants, eight children, and eight adolescents, were studied. They received simultaneous, primed, constant, intravenous infusions of l-[(2)H(3)]methylmethionine and enteral l-[1-(13)C]methionine. The ratio of [(13)C]homocysteine to [(13)C]methionine enrichment was 1.0 ± 0.15, 0.80 ± 0.20, and 0.66 ± 0.10, respectively, for the infants, children, and adolescents, and it was different between the infants and adolescents (P < 0.01). Methionine splanchnic uptake was 63, 45, and 36%, respectively, in the infants, children, and adolescents, and it was higher (P < 0.01) in the infants compared with the adolescents. The infants utilized 73% of methionine flux for nonoxidative disposal, while 27% was used for transulfuration (P < 0.001). Conversely, in the adolescents, 40% was utilized for nonoxidative disposal, while 60% was used for transulfuration. There is ontogeny on the rates of methionine splanchnic uptake and on the fate of methionine utilization in critically ill children, with greater methionine utilization for synthesis of proteins and methionine-derived compounds (P < 0.01) and decreased transulfuration rates in the infants (P < 0.01), while the opposite was observed in the adolescents. The plasma model underestimated methionine kinetics in children and adolescents but not in the infants, suggesting lesser dilution and greater compartmentation of methionine metabolism in the infant population. All patients were in negative methionine balance, indicating that the current enteral nutritional support is inadequate in these patients.
Authors:
Sascha Verbruggen; Jama Sy; William E Gordon; Jean Hsu; Manhong Wu; Shaji Chacko; David Zurakowski; Douglas Burrin; Leticia Castillo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-09-01
Journal Detail:
Title:  American journal of physiology. Endocrinology and metabolism     Volume:  297     ISSN:  1522-1555     ISO Abbreviation:  Am. J. Physiol. Endocrinol. Metab.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2012-01-30     Completed Date:  2012-03-13     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  100901226     Medline TA:  Am J Physiol Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  E1046-55     Citation Subset:  IM    
Affiliation:
Texas Children's Hospital, Children's Nutrition Research Center, USDA/ARS at Baylor College Medicine, 1100 Bates St., Houston, TX 77030, USA.
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MeSH Terms
Descriptor/Qualifier:
Abdomen / physiology*
Adolescent
Aging / metabolism
Algorithms
Carbon Dioxide / metabolism
Child
Child, Preschool
Critical Illness*
Diet
Enteral Nutrition
Female
Homocysteine / metabolism
Humans
Infant
Isotope Labeling
Kinetics
Male
Methionine / metabolism*,  pharmacokinetics
Oxidation-Reduction
Grant Support
ID/Acronym/Agency:
25337387//PHS HHS; DK-62363/DK/NIDDK NIH HHS; M01-RR-00188/RR/NCRR NIH HHS; T32 HD-007445/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
124-38-9/Carbon Dioxide; 454-28-4/Homocysteine; 63-68-3/Methionine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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