Document Detail


Ontogeny of mammalian metabolizing enzymes in humans and animals used in toxicological studies.
MedLine Citation:
PMID:  22512665     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
It is well recognized that expression of enzymes varies during development and growth. However, an in-depth review of this acquired knowledge is needed to translate the understanding of enzyme expression and activity into the prediction of change in effects (e.g. kinetics and toxicity) of xenobiotics with age. Age-related changes in metabolic capacity are critical for understanding and predicting the potential differences resulting from exposure. Such information may be especially useful in the evaluation of the risk of exposure to very low (µg/kg/day or ng/kg/day) levels of environmental chemicals. This review is to better understand the ontogeny of metabolizing enzymes in converting chemicals to either less-toxic metabolite(s) or more toxic products (e.g. reactive intermediate[s]) during stages before birth and during early development (neonate/infant/child). In this review, we evaluated the ontogeny of major "phase I" and "phase II" metabolizing enzymes in humans and commonly used experimental animals (e.g. mouse, rat, and others) in order to fill the information gap.
Authors:
Shakil Ahmed Saghir; Sarosh Ahmed Khan; Alene Theresa McCoy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical reviews in toxicology     Volume:  42     ISSN:  1547-6898     ISO Abbreviation:  Crit. Rev. Toxicol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914275     Medline TA:  Crit Rev Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-57     Citation Subset:  IM    
Affiliation:
Toxicology & Environmental Research & Consulting , The Dow Chemical Company, Midland, Michigan , USA.
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