Document Detail


Ontogeny of intestinal nutrient transport.
MedLine Citation:
PMID:  10926157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Children born prematurely lack the ability to digest and to absorb nutrients at rates compatible with their nutritional needs. As a result, total parenteral nutrition may need to be given. While this nutritional support may be lifesaving, the baby who receives this therapy is exposed to the risks of possible sepsis, catheter dysfunction, and liver disease. The rodent model of postnatal development provides a useful framework to investigate some of the cellular features of human intestinal development. The up-regulation of intestinal gene expression and precocious development of intestinal nutrient absorption can be achieved by providing growth factor(s) or by modifying the composition of the maternal diet during pregnancy and nursing or the weaning diet of the infant. Accelerating the digestive and absorptive functions of the intestine would thereby allow for the maintenance of infant nutrition through oral food intake, and might possibly eliminate the need for, and risks of, total parenteral nutrition. Accordingly, this review was undertaken to focus on the adaptive processes available to the intestine, to identify what might be the signals for and mechanisms of the modified nutrient absorption, and to speculate on approaches that need to be studied as means to possibly accelerate the adaptive processes in ways which would be beneficial to the newborn young.
Authors:
A Thiesen; G Wild; M Keelan; M T Clandinin; M McBurney; J Van Aerde; A B Thomson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  78     ISSN:  0008-4212     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-11-28     Completed Date:  2000-11-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  513-27     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Alberta, Edmonton, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adrenal Cortex Hormones / pharmacology
Animals
Biological Transport / drug effects
Genes, myc / physiology
Growth Hormone / pharmacology
Humans
Infant, Newborn
Intestinal Absorption* / drug effects
Ornithine Decarboxylase / metabolism
Chemical
Reg. No./Substance:
0/Adrenal Cortex Hormones; 9002-72-6/Growth Hormone; EC 4.1.1.17/Ornithine Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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