| Ontogeny of glucose homeostasis in low birth weight infants. | |
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MedLine Citation:
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PMID: 3279177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Suppression of the endogenous glucose production rate (Ra) is the adult response to glucose infusion. Persistent Ra (greater than or equal to 1 mg.kg-1min-1 or less than 80% decrease in basal Ra) in response to glucose infusion is evidence of a transitional homeostatic state in the neonate during the first days after birth. To determine whether postnatal development produces an adultlike response, Ra was measured in 11 infants (birth weight 1716 +/- 48 g, gestational age 33 +/- 0.3 weeks) at 2 to 5 weeks of age. In these paired studies, 4 micrograms.kg-1min-1 D-(U-13C)glucose tracer was infused by prime constant infusion to determine Ra, during infusion of either saline solution or glucose, the latter at a rate of 5.3 +/- 0.2 mg.kg-1min-1 (mean +/- SEM). When the results of the saline infusion turnover period were compared with those of the glucose infusion turnover period, plasma glucose concentration increased significantly, from 88 +/- 3 mg/dL to 101 +/- 4 mg/dL (P less than 0.001). Plasma insulin concentration remained unchanged (12 +/- 5 microU/mL vs 8 +/- 3 microU/mL). Ra was heterogenous during glucose infusion, and persistent Ra was present in six of 11 infants. Of the five infants who had decreased Ra during glucose infusion, three received glucose at a rate exceeding basal Ra. Of the remaining six infants who evidenced persistent Ra during glucose infusion, three received glucose at a rate equal to or in excess of basal Ra. We conclude that glucose homeostasis in low birth weight infants is transitional throughout the neonatal period. |
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Authors:
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R M Cowett; G E Andersen; C A Maguire; W Oh |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of pediatrics Volume: 112 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1988 Mar |
Date Detail:
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Created Date: 1988-04-14 Completed Date: 1988-04-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 462-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Women and Infants Hospital of Rhode Island, Providence 02905-2401. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Blood Glucose / biosynthesis, metabolism* Glucose / administration & dosage Homeostasis* Humans Infant Infant, Low Birth Weight / metabolism* Infant, Newborn Insulin / blood |
| Grant Support | |
ID/Acronym/Agency:
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K04-HD-00308/HD/NICHD NIH HHS; NICHHD 11343/HD/NICHD NIH HHS; RR02231/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 11061-68-0/Insulin; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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