Document Detail

Ontogeny of the generation of diiodothyronines (3,3'-T2 and 3',5'-T2) from triiodothyronines in the liver and kidney during the fetal life of the pig.
MedLine Citation:
PMID:  8908744     Owner:  NLM     Status:  MEDLINE    
The present study was conducted to obtain information on the generation of diiodothyronines from triiodothyronines (3,3'-T2 from T3, and rT3, and 3',5'-T2 from rT3) as a result of the activity of the tissue monodeiodinase enzymes (MD) in the liver and kidney of pig fetuses and their mothers between 32 and 113 days of gestation. T3-5-MD activity in the fetal kidney during the gestational period was stable and higher than in the liver and in the maternal kidney. In contrast, T3-5-MD activity of the liver was 3-4 times lower in fetal than in maternal tissue in the first half of pregnancy, and in the second half of pregnancy 3,3'-T2 production from T3 in the maternal liver was equal to, or lower than, that in the fetal liver. The activity of MD deiodinating rT3 (3,3'-T2 and 3',5'-T2 generation) increased significantly in fetal liver and kidney in the last 2-3 weeks of pregnancy and was higher than in maternal tissues. In both tissues examined the inner ring deiodinating activity (IRD) was 5-10 times lower as compared to the outer ring (ORD).
E Krysin; E Brzezińska-Slebodzińska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta veterinaria Hungarica     Volume:  44     ISSN:  0236-6290     ISO Abbreviation:  Acta Vet. Hung.     Publication Date:  1996  
Date Detail:
Created Date:  1996-12-05     Completed Date:  1996-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8406376     Medline TA:  Acta Vet Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  203-12     Citation Subset:  IM    
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences in Olsztyn, Department of Developmental and Experimental Endocrinology, Poznań, Poland.
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MeSH Terms
Diiodothyronines / metabolism*
Embryonic and Fetal Development*
Gestational Age
Kidney / embryology,  metabolism*
Liver / embryology,  metabolism*
Triiodothyronine / metabolism*
Triiodothyronine, Reverse / metabolism
Reg. No./Substance:
0/Diiodothyronines; 534-51-0/3,5-diiodothyronine; 5817-39-0/Triiodothyronine, Reverse; 60363-25-9/3',5'-diiodothyronine; 6893-02-3/Triiodothyronine

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