Document Detail

Ontogeny of gastric acid secretion in the rat: evidence for multiple response systems.
MedLine Citation:
PMID:  6211765     Owner:  NLM     Status:  MEDLINE    
Gastric acid secretion has been thought to depend on histamine stimulation of the parietal cell. However, in the 2-week-old rat neither exogenous histamine nor the H-2 receptor agonist impromidine stimulates acid secretion, whereas pentagastrin and the cholinergic agent bethanechol are potent stimuli. At this age, the effect of pentagastrin in acid secretion is not blocked by the H-2 receptor antagonist cimetidine, nor is it potentiated by impromidine. These data suggest that, in the rat pup, the acid secretory response to pentagastrin and cholinergic agents occurs before the histamine-mediated system is functional and operates independently of the actions of histamine.
S H Ackerman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  217     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-08-07     Completed Date:  1982-08-07     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  75-7     Citation Subset:  IM    
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MeSH Terms
Bethanechol Compounds / pharmacology
Gastric Juice / drug effects,  secretion*
Gastric Mucosa / growth & development
Guanidines / pharmacology
Histamine / pharmacology
Imidazoles / pharmacology
Pentagastrin / pharmacology
Rats, Inbred Strains
Receptors, Histamine H2 / drug effects
Grant Support
Reg. No./Substance:
0/Bethanechol Compounds; 0/Guanidines; 0/Imidazoles; 0/Receptors, Histamine H2; 51-45-6/Histamine; 55273-05-7/Impromidine; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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