Document Detail

Ontogeny of adrenal VIP content and release from adrenocortical cells in the ovine fetus.
MedLine Citation:
PMID:  2834698     Owner:  NLM     Status:  MEDLINE    
The present study was designed to investigate the presence of VIP in fetal adrenals, to determine the changes in adrenal VIP content associated with maturation, and to explore the factors which regulate fetal adrenal VIP release. Adrenal glands from ovine fetuses at 70 to 140 days gestation were used. Adrenal VIP content, as measured by radioimmunoassay, were low at 70 and 80 days of gestation. This was followed by a rapid increase in VIP content from 80 to 110 days reaching a plateau between 110 and 130 days at levels comparable to that in the adult. A significant fall in adrenal VIP content occurred at 140 days, immediately prior to term. Release of VIP from fetal adrenocortical cells in vitro was significantly elevated by angiotensin II at 10(-5) M, while ACTH had no effect. Acetylcholine at 50 microM and high potassium stimulated fetal adrenal VIP release while norepinephrine did not. These results suggest that the VIP neuronal system in the ovine fetal adrenal matures between 80 and 110 days of gestation. Furthermore, the release of VIP from the fetal adrenocortical cells may be regulated by angiotensin II and cholinergic neurotransmitters.
C Y Cheung
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Peptides     Volume:  9     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:    1988 Jan-Feb
Date Detail:
Created Date:  1988-05-31     Completed Date:  1988-05-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  107-11     Citation Subset:  IM    
Department of Reproductive Medicine, School of Medicine, University of California, San Diego, La Jolla 92093.
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MeSH Terms
Acetylcholine / pharmacology
Adrenal Cortex / drug effects,  embryology,  secretion*
Adrenocorticotropic Hormone / pharmacology
Angiotensin II / pharmacology
Cells, Cultured
Fetus / metabolism*
Gestational Age
Norepinephrine / pharmacology
Sheep / embryology*
Vasoactive Intestinal Peptide / immunology,  secretion*
Grant Support
Reg. No./Substance:
11128-99-7/Angiotensin II; 37221-79-7/Vasoactive Intestinal Peptide; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 9002-60-2/Adrenocorticotropic Hormone

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