| Ontogeny of T cells, B cells and monocytes in the bovine foetus. | |
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MedLine Citation:
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PMID: 314369 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ontogeny of lymphocyte subpopulations and monocytes was studied in developing bovine foetuses. Fifty-four bovine foetuses ranging in age from 3 to 9 months of gestation were collected and examined for the presence of thymus-derived (T lymphocytes), bone marrow-derived (B lymphocytes) and phagocytic (macrophage) cells from thymus, spleen and peripheral blood. Detection of the cells expressing T lymphocyte surface markers was done using a modified sheep red blood cell rosette assay. Lymphocytes bearing surface immunoglobulin (sIg) were detected by staining with a fluoresceinated rabbit antibody prepared against bovine IgG. The procedure used for detecting monocytes was a latex bead phagocytic assay. In the thymus, the percentage of T lymphocytes was relatively constant throughout gestation at approximately 60-70%, with B lymphocytes remaining at about 1%, whereas the phagocytic cells showed an increase from 1% at 3 months to approximately 8% at term. The spleen showed an increasing percentage of T lymphocytes, from 11% at 3 months to over 40% at term, whereas the percentage of B lymphocytes remained consistent at about 2-3% from 3 months until term. The percentage of monocytes increases from 1% at 3 months to over 20% at 9 months. Peripheral blood T lymphocytes increased steadily from approximately 1% at 3 months to 45% at term. B lymphocyte levels remained low, about 1%, throughout gestation, whereas monocytes increased from 1% at 3 months to 5% at 9 months. |
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Authors:
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D R Senogles; P S Paul; D W Johnson; C C Muscoplat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 36 ISSN: 0009-9104 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 1979 May |
Date Detail:
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Created Date: 1979-11-21 Completed Date: 1979-11-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 299-303 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals B-Lymphocytes / immunology* Cattle Fetus / immunology* Gestational Age Leukocyte Count Monocytes / immunology* Phagocytosis Receptors, Antigen, B-Cell / analysis Rosette Formation Spleen / embryology T-Lymphocytes / immunology* Thymus Gland / embryology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, B-Cell |
| Comments/Corrections | |
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