| Ontogeny of Cardiac Sympathetic Innervation and Its Implications for Cardiac Disease. | |
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MedLine Citation:
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PMID: 22395650 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into the etiology of cardiac arrhythmogenesis. This review provides an overview of the cell signaling pathways and transcriptional effectors that regulate both the noradrenergic gene program during sympathetic neurogenesis and regional nerve density during cardiac innervation. Recent studies exploring transcriptional regulation of the bHLH transcription factor Hand1 in developing sympathetic neurons are explored, and how the Hand1 sympathetic neuron-specific cis-regulatory element may be used further to assess the contribution of altered sympathetic innervation to human cardiac disease is discussed. |
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Authors:
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Joshua W Vincentz; Michael Rubart; Anthony B Firulli |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-3 |
Journal Detail:
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Title: Pediatric cardiology Volume: - ISSN: 1432-1971 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003849 Medline TA: Pediatr Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Pediatric Cardiology, Departments of Anatomy, Biochemistry, and Medical and Molecular Genetics, Riley Heart Research Center, Wells Center for Pediatric Research, Indiana Medical School, 1044W. Walnut Street, Indianapolis, IN, 46202-5225, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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