Document Detail


Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease.
MedLine Citation:
PMID:  22395650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The vertebrate heart is innervated by the sympathetic and parasympathetic components of the peripheral autonomic nervous system, which regulates its contractile rate and force. Understanding the mechanisms that control sympathetic neuronal growth, differentiation, and innervation of the heart may provide insight into the etiology of cardiac arrhythmogenesis. This review provides an overview of the cell signaling pathways and transcriptional effectors that regulate both the noradrenergic gene program during sympathetic neurogenesis and regional nerve density during cardiac innervation. Recent studies exploring transcriptional regulation of the bHLH transcription factor Hand1 in developing sympathetic neurons are explored, and how the Hand1 sympathetic neuron-specific cis-regulatory element may be used further to assess the contribution of altered sympathetic innervation to human cardiac disease is discussed.
Authors:
Joshua W Vincentz; Michael Rubart; Anthony B Firulli
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-03-03
Journal Detail:
Title:  Pediatric cardiology     Volume:  33     ISSN:  1432-1971     ISO Abbreviation:  Pediatr Cardiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-10     Completed Date:  2013-04-25     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  8003849     Medline TA:  Pediatr Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  923-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Basic Helix-Loop-Helix Transcription Factors / genetics,  metabolism*
Cell Differentiation
Gene Expression Regulation
Heart / innervation*
Heart Diseases / etiology
Humans
Neurogenesis*
Signal Transduction
Sympathetic Nervous System / anatomy & histology,  growth & development*,  metabolism
Grant Support
ID/Acronym/Agency:
1P01HL085098-05/HL/NHLBI NIH HHS; P01 HL085098/HL/NHLBI NIH HHS; P01 HL085098-05/HL/NHLBI NIH HHS; R01 AR061392/AR/NIAMS NIH HHS; R01 HL061677/HL/NHLBI NIH HHS; R01 HL061677-12/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Basic Helix-Loop-Helix Transcription Factors; 0/helix-loop-helix protein, eHAND
Comments/Corrections

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