| Ontogeny of CD24 in the human kidney. | |
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MedLine Citation:
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PMID: 20336055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The heat-stable antigen, CD24, is a cell-surface sialoglycoprotein expressed on immature cells that disappears after they have reached their final stage of differentiation. In mice, CD24 expression is preferentially upregulated in the developing mouse metanephros as compared with the surrounding intermediate mesoderm, but its role and expression in the developing human kidney has not been well described. Here we found in normal human fetal kidneys (8 to 38 weeks of gestation) that CD24 expression was upregulated and restricted to the early epithelial aggregates of the metanephric blastema and to the committed proliferating tubular epithelia of the S-shape bodies. Individual cells expressing CD24 were identified in the interstitium of later gestation and postnatal kidneys. In freshly isolated cells, FACS analysis identified distinct CD24(+) and CD24(+)133(+) cell populations constituting up to 16 and 14 percent, respectively, of the total cells analyzed. Early fetal urinary tract obstruction resulted in upregulation of CD24 expression both in developing epithelial structures of early stages and in the cells of the injured tubular epithelium of the later gestation kidneys. Our results highlight the cell-specific expression of CD24 in the developing human kidney and its dysregulation during fetal urinary tract obstruction. |
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Authors:
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Larissa Ivanova; Michael J Hiatt; Mervin C Yoder; Alice F Tarantal; Douglas G Matsell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-03-24 |
Journal Detail:
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Title: Kidney international Volume: 77 ISSN: 1523-1755 ISO Abbreviation: Kidney Int. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-28 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
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Languages: eng Pagination: 1123-31 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada V6H 3V4. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, CD24
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analysis*,
genetics Fetus Flow Cytometry Gestational Age Humans Kidney / cytology, embryology, growth & development* Tissue Distribution Up-Regulation* Ureteral Obstruction |
| Grant Support | |
ID/Acronym/Agency:
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HL085036/HL/NHLBI NIH HHS; RR00169/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD24 |
| Comments/Corrections | |
Comment In:
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Kidney Int. 2010 Sep;78(6):620-1; author reply 621
[PMID:
20805819
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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