Document Detail

Ontogenic development of gastrointestinal motility: IV. Duodenal contractions in preterm infants.
MedLine Citation:
PMID:  3097617     Owner:  NLM     Status:  MEDLINE    
Duodenal motility was studied by intraluminal manometry in 27 healthy infants of 26 to 42 weeks, gestational age. The frequency of contractions, the number of contractions per burst, and the intraluminal peak pressure during contractions all increased during a narrow postconceptual period, 29 to 32 weeks, regardless of length of gestation before birth. Antenatal beta-methasone administration to the mothers of 11 additional infants of 26 to 32 weeks gestational age was associated with increased duodenal contraction rate, number of contractions per burst, and intraluminal peak pressure compared with infants of similar gestational age whose mothers did not receive beta-methasone. The maturational effect of beta-methasone on duodenal motility was most pronounced in infants whose gestational age at birth was 26 to 29 weeks. Seven infants of 31 weeks' or longer gestational duration who had a CNS abnormality or insult had fasting duodenal contraction rates that were less than one half of the rate for normal infants of similar gestational age. These observations suggest that neonatal duodenal motility undergoes marked maturational changes between 29 and 32 weeks after conception and that these changes may be inducible before 29 weeks by corticosteroid administration. An intact CNS appears to be required for full expression of the maturational changes.
F H Morriss; M Moore; N W Weisbrodt; M S West
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pediatrics     Volume:  78     ISSN:  0031-4005     ISO Abbreviation:  Pediatrics     Publication Date:  1986 Dec 
Date Detail:
Created Date:  1987-01-05     Completed Date:  1987-01-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1106-13     Citation Subset:  AIM; IM    
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MeSH Terms
Betamethasone / administration & dosage,  pharmacology
Central Nervous System Diseases / physiopathology
Duodenum / drug effects,  growth & development,  physiology*,  physiopathology
Enteral Nutrition
Gastrointestinal Motility* / drug effects
Gestational Age
Infant, Newborn
Infant, Premature / growth & development,  physiology*
Infant, Premature, Diseases / physiopathology
Maternal-Fetal Exchange
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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