Document Detail


Ontogenic changes in placental transthyretin.
MedLine Citation:
PMID:  21945519     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Before secretion of fetal thyroid hormone at around 16 weeks gestation normal fetal development depends on a constant supply of maternal thyroid hormone (TH), particularly thyroxine (T(4)). The detailed mechanisms of transplacental delivery of TH are still uncertain. The TH binding protein, transthyretin (TTR), is produced and secreted by placenta and may play a role in this process. The ontogeny of placental TTR is unknown. Our aim was to study changes in placental TTR in early and late pregnancy. STUDY DESIGN: We collected placentas from surgically terminated pregnancies between 6 and 17 weeks gestation (n = 44) and from normal term (38-39 weeks) pregnancies following caesarean section (n = 5). Real time-PCR, western blotting and immunohistochemistry were used to determine TTR mRNA and protein levels. RESULTS: There were highly significant correlations between gestational age and TTR mRNA (r = 0.974; p < 0.0001) and between gestational age and TTR protein (r = 0.901; p < 0.001) levels between weeks 6 and 13 of gestation. TTR expression did not increase between 13 and 17 weeks and was not different at term. Good correlation was observed between TTR mRNA and TTR protein between individual placental samples (r = 0.916; p < 0.0001). A similar trend was observed using immunohistochemical staining of placental paraffin sections. CONCLUSIONS: Our results demonstrate that TTR is expressed in the human placenta from at least 6 weeks gestation. Levels rise during the first trimester at a time when placental oxygen tensions are also rising. We hypothesise that TTR production and secretion by the placenta may facilitate transplacental delivery of TH to the fetus.
Authors:
J Patel; K A Landers; H Li; R H Mortimer; K Richard
Related Documents :
21732739 - Pregnancy outcome in women following splenectomy.
21675879 - Pentalogy or hexalogy of cantrell?
21715699 - Daily ethanol exposure during late ovine pregnancy: physiological effects in the mother...
21806579 - Improvement in pregnancy rate by removal of cervical discharge prior to embryo transfer...
21895569 - Ambivalence, communication and past use: understanding what influences women's intentio...
21801139 - Sonographic study of the relationship between gestational diabetes mellitus and fetal a...
3760659 - Clinical study on embryo transfer after human in vitro fertilization.
22368179 - Organochlorine pesticide residues in biological compartments of healthy mothers.
15935839 - Hysterographic appearance and uterine histology at different stages of the reproductive...
Publication Detail:
Type:  -     Date:  2011-9-24
Journal Detail:
Title:  Placenta     Volume:  -     ISSN:  1532-3102     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Crown Copyright © 2011. Published by Elsevier Ltd. All rights reserved.
Affiliation:
School of Medicine, The University of Queensland, Herston 4006, Brisbane, Australia; Conjoint Endocrine Laboratory, Royal Brisbane and Women's Hospital, 300 Herston Rd, Herston, Brisbane, Queensland 4029, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Epidemiology and etiology of mantle cell lymphoma and other non-Hodgkin lymphoma subtypes.
Next Document:  Mitochondrial adenine nucleotide transport and cardioprotection.