| Ontogenic changes in human placental sodium iodide symporter expression. | |
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MedLine Citation:
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PMID: 22954554 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The human fetus requires a maternal supply of iodide to synthesize thyroid hormone from 16 weeks gestation. Placental iodide transport is regulated by the sodium iodide symporter (NIS). We studied the ontogeny of NIS in placentas from surgically terminated pregnancies and from normal term pregnancies. NIS mRNA was low at 6 weeks gestation and peaked at 12 weeks gestation. Placental NIS protein levels are significantly correlated with gestational age during early pregnancy and increase with increased placental vascularization. This would lead to increased iodide supply to meet increased fetal requirements for thyroid hormone synthesis as the pregnancy progresses. |
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Authors:
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H Li; J Patel; R H Mortimer; K Richard |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-3 |
Journal Detail:
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Title: Placenta Volume: - ISSN: 1532-3102 ISO Abbreviation: Placenta Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8006349 Medline TA: Placenta Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Conjoint Endocrine Laboratory, Pathology Queensland, Royal Brisbane and Women's Hospital, Herston, 4029 Brisbane, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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