Document Detail

Ontogenetic transition of cardiac myosin heavy chain isoforms in rat ventricle: effects of fetal exposure to beta-adrenergic agonists or antagonists.
MedLine Citation:
PMID:  1357026     Owner:  NLM     Status:  MEDLINE    
Cardiac myosin heavy chain (MHC) expression undergoes an ontogenetic transition from beta to alpha MHC isoforms. Although thyroid hormone plays a role in this change, the timing of the events suggests the participation of other factors. Using a new, denaturing SDS-PAGE procedure that cleanly resolves the beta and alpha heavy chains, we have assessed the role of beta-adrenergic stimulation on this transition in fetal and neonatal rat hearts. In control animals at embryonic day 20, less than 15% of the MHC was the alpha-form, and the proportion increased to approximately 35% by postnatal day 1 and to 80% by postnatal day 8. Although catecholamine levels rise abruptly at birth, and cyclic AMP levels increase the expression of alpha-MHC in vitro, neither premature beta-adrenergic stimulation (maternal treatment with terbutaline on embryonic days 17, 18 and 19) nor continuous prenatal blockade of beta-receptors (maternal propranolol infusions from embryonic day 7 onward) influenced the developmental profile. Because beta-receptors in fetal and neonatal heart are functionally linked to adenylate cyclase, and cyclic AMP has been shown to promote the expression of alpha-MHC, the lack of effect of terbutaline or propranolol suggests that activation of adenylate cyclase through fetal cardiac beta-receptors is not sufficient to mediate the switchover without participation of other factors, such as thyroid or steroid hormones, or hypoxia.
M M Briggs; F J Seidler; T A Slotkin; F H Schachat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  17     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-11-17     Completed Date:  1992-11-17     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  201-6     Citation Subset:  IM    
Department of Cell Biology, Duke University Medical Center, Durham, North Carolina 27710.
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MeSH Terms
Adrenergic beta-Agonists / pharmacology
Adrenergic beta-Antagonists / pharmacology
Animals, Newborn
Fetal Heart / drug effects*
Heart Ventricles
Isoenzymes / chemistry,  metabolism*
Myocardium / enzymology*
Myosins / chemistry,  metabolism*
Prenatal Exposure Delayed Effects
Rats, Sprague-Dawley
Sympathomimetics / pharmacology*
Reg. No./Substance:
0/Adrenergic beta-Agonists; 0/Adrenergic beta-Antagonists; 0/Isoenzymes; 0/Sympathomimetics; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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