Document Detail


Ontogenetic and phylogenetic evaluation of the presence of fibrin-type fibrinoid in the villous haemochorial placenta.
MedLine Citation:
PMID:  9290158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothesis that fibrin type fibrinoid deposition on villi is unique to the term human placenta was tested. Bright-field microscopy was used to examine sections of first and second trimester human placental villi and tissues from three animal species that have villous haemochorial placentae similar to the human: the armadillo, the baboon and the rhesus. Sections stained with haematoxylin and eosin showed fibrin type fibrinoid deposits were hypocellular, eosinophilic masses attached to the surface of villi examined from both the human and the animal species. The deposits were located at discontinuities in the syncytiotrophoblast layer, and the fibrinoid provided a matrix for trophoblast re-epithelization of the villous surface. It is concluded that fibrin-type fibrinoid is not unique to the term human placenta. The presence of the syncytiotrophoblast discontinuities associated with the fibrinoid deposition must be considered in models of maternal-fetal exchange in the villous haemochorial placenta.
Authors:
D M Nelson; P E Swanson; B B Davison; G B Baskin; A C Enders
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Placenta     Volume:  18     ISSN:  0143-4004     ISO Abbreviation:  Placenta     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-15     Completed Date:  1997-10-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  605-8     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Washington University School of Medicine, St Louis, Missouri, USA. nelson_dm@kids.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Armadillos
Chorionic Villi / chemistry*
Coloring Agents
Eosine Yellowish-(YS)
Female
Fibrin / analysis*
Hematoxylin
Humans
Immunoenzyme Techniques
Macaca mulatta
Papio
Phylogeny*
Pregnancy
Grant Support
ID/Acronym/Agency:
R01 HD29190/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Coloring Agents; 17372-87-1/Eosine Yellowish-(YS); 517-28-2/Hematoxylin; 9001-31-4/Fibrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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