| Ontogenetic development of the diencephalic MCH neurons: a hypothalamic 'MCH area' hypothesis. | |
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MedLine Citation:
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PMID: 11359525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ontogeny of rat diencephalic melanin-concentrating hormone (MCH) neurons has been analysed, using the bromodeoxyuridine method to determine the period of birth of these neurons, and using in situ hybridization and immunohistochemistry to study their chemical differentiation. The spatiotemporal pattern of MCH neuron generation is complex, although it is broadly lateromedial with a peak between embryonic days (E) 12 and E13. The first expression of the MCH gene has been detected on E13 in neurons in the presumptive lateral hypothalamic area. But the adult-like pattern was observed from E18. Medial-most MCH neurons express the peptide CART (cocaine-amphetamine-regulated transcript) from E18, and the receptor neurokinin 3 (NK3) from between postnatal day (P) 0 and P5. These results are discussed and compared with data from the literature to better understand the organization of the 'MCH-containing area'. |
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Authors:
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F Brischoux; D Fellmann; P Y Risold |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The European journal of neuroscience Volume: 13 ISSN: 0953-816X ISO Abbreviation: Eur. J. Neurosci. Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-05-21 Completed Date: 2001-07-26 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8918110 Medline TA: Eur J Neurosci Country: France |
Other Details:
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Languages: eng Pagination: 1733-44 Citation Subset: IM |
Affiliation:
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Laboratoire d'Histologie, Embryologie, Cytogénétique, CNRS FRE 2174, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Place St Jacques, 25030 Besançon Cedex, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Bromodeoxyuridine / pharmacokinetics Cell Differentiation / physiology* Embryo, Mammalian Gene Expression Regulation, Developmental / physiology* Hypothalamic Hormones / genetics, metabolism* Hypothalamus / cytology, embryology*, growth & development Immunohistochemistry Melanins / genetics, metabolism* Nerve Tissue Proteins / metabolism Neurons / cytology, metabolism* Pituitary Hormones / genetics, metabolism* RNA, Messenger / metabolism Rats Rats, Sprague-Dawley Receptors, Neurokinin-3 / metabolism Stem Cells / cytology, metabolism* Tyrosine 3-Monooxygenase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Hypothalamic Hormones; 0/Melanins; 0/Nerve Tissue Proteins; 0/Pituitary Hormones; 0/RNA, Messenger; 0/Receptors, Neurokinin-3; 0/cocaine- and amphetamine-regulated transcript protein; 59-14-3/Bromodeoxyuridine; 67382-96-1/melanin-concentrating hormone; EC 1.14.16.2/Tyrosine 3-Monooxygenase |
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