Document Detail

Ontogenetic appearance of somatostatin-containing nerve terminals in the median eminence of rats.
MedLine Citation:
PMID:  6143619     Owner:  NLM     Status:  MEDLINE    
The development of immunoreactive (ir) somatostatin-containing nerve terminals in the rat median eminence (ME) has been examined electron-microscopically. Nerve fibers containing ir particles scattered throughout the axoplasm are first seen in the external layer of the ME on day 18.5 of gestation, and, on day 21.5 appear to terminate on the basement membrane of the perivascular space of the portal vessels. After birth, the fiber terminals contain several membrane-limited granules, which are labeled with ir PAP particles. Ultrathin, Epon-embedded sections of ME, treated by the protein A gold-labeling method for somatostatin, demonstrate positively labeled granules in the nerve fibers in the postnatal ME, but in the prenatal tissue, no specific gold-labeling is found. These findings show that, in the external layer of the ME, somatostatin storing occurs in the granules in the axonal terminals after birth.
T Adachi; M Ohtsuka; S Hisano; Y Tsuruo; S Daikoku
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell and tissue research     Volume:  236     ISSN:  0302-766X     ISO Abbreviation:  Cell Tissue Res.     Publication Date:  1984  
Date Detail:
Created Date:  1984-06-08     Completed Date:  1984-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417625     Medline TA:  Cell Tissue Res     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
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MeSH Terms
Animals, Newborn
Median Eminence / embryology,  growth & development*,  ultrastructure
Microscopy, Electron
Neurons / ultrastructure*
Rats, Inbred Strains
Somatostatin / analysis*
Reg. No./Substance:

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