| Onset time, quality of blockade, and duration of three-in-one blocks with levobupivacaine and bupivacaine. | |
| | |
MedLine Citation:
|
PMID: 12933423 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Levobupivacaine is the isolated S(-)-stereoisomer of racemic bupivacaine. Important pharmacodynamic properties of levobupivacaine have not been determined for the femoral three-in-one block. In this randomized, controlled, double-blinded trial, we studied 60 ASA physical status I-III patients scheduled for surgery of the lower limb. A nerve-stimulator-guided three-in-one block was performed as supplemental analgesic therapy with 20 mL of bupivacaine 0.5% (n = 20), levobupivacaine 0.5% (n = 20), or levobupivacaine 0.25% (n = 20). Sensory onset time, quality of blockade, and duration of blockade were assessed by pinprick test in the central sensory innervation region of the femoral nerve (distribution of the anterior femoral cutaneous nerve). A rating scale from 100% (normal sensation) to 0% (no sensation at all) as compared with the contralateral leg was used. No significant difference in sensory onset time among the three local anesthetic solutions was observed (mean [95% confidence interval]): bupivacaine 0.5%, 27 min (20-33 min); levobupivacaine 0.5%, 24 min (18-30 min); and levobupivacaine 0.25%, 30 min (23-36 min) (P = 0.49). The analgesic quality of the blockade was also not significantly different among the three groups, whereas a complete sensory block was achieved in significantly fewer patients in the levobupivacaine 0.25% group (P = 0.02). The duration of blockade was significantly shorter with levobupivacaine 0.25% compared with the other groups: bupivacaine 0.5%, 1053 min (802-1304 min); levobupivacaine 0.5%, 1001 min (844-1158 min); and levobupivacaine 0.25%, 707 min (551-863 min) (P = 0.01). Levobupivacaine 0.5% is recommended instead of bupivacaine 0.5% for the three-in-one block. |
| | |
Authors:
|
Bernhard Urbanek; Andreas Duma; Oliver Kimberger; Gudrun Huber; Peter Marhofer; Michael Zimpfer; Stephan Kapral |
Related Documents
:
|
11064623 - Peribulbar anaesthesia with 1% ropivacaine and hyaluronidase 300 iu ml-1: comparison wi... 3232783 - Dependence of the output of a halothane vaporizer on thymol concentration. 468603 - Ventilation and gas exchange during phasic hindlimb exercise in the dog. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 97 ISSN: 0003-2999 ISO Abbreviation: Anesth. Analg. Publication Date: 2003 Sep |
Date Detail:
|
Created Date: 2003-08-22 Completed Date: 2003-09-15 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
|
Languages: eng Pagination: 888-92 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anesthesiology and General Intensive Care, University of Vienna, Vienna, Austria. bernhard.urbanek@gmx.at |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Anesthetics, Local* Bupivacaine* Double-Blind Method Female Humans Male Middle Aged Nerve Block* Orthopedic Procedures Pain Measurement / drug effects Stereoisomerism |
| Chemical | |
Reg. No./Substance:
|
0/Anesthetics, Local; 2180-92-9/Bupivacaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Epidural blood patch placed in the presence of an unknown cervical epidural hematoma.
Next Document: Pulmonary uptake of ropivacaine and levobupivacaine in rabbits.