Document Detail

Onset of terminal decline in cognitive abilities in individuals without dementia.
MedLine Citation:
PMID:  18753475     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To identify time of onset and rate of mortality-related change (terminal decline) in cognitive abilities in later life. METHOD: The sample consisted of 288 individuals without dementia (born 1901-1902) drawn from the population of Göteborg, Sweden. Participants were followed from age 70 until death, with up to 12 measurement occasions on three cognitive abilities. Change-point analysis was performed using an automated piecewise linear mixed modeling approach to identify the inflection point indicating accelerated within-person change related to mortality. A profile likelihood method was used to identify the change point that best fit the data for each of three cognitive abilities. RESULTS: Onset of terminal decline was identified 6.6 years prior to death for verbal ability, 7.8 years for spatial ability, and 14.8 years for perceptual speed. CONCLUSIONS: There is substantial acceleration in cognitive decline many years prior to death among individuals without dementia. Time of onset and rate of terminal decline vary considerably across cognitive abilities.
V Thorvaldsson; S M Hofer; S Berg; I Skoog; S Sacuiu; B Johansson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-27
Journal Detail:
Title:  Neurology     Volume:  71     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2008-10-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  882-7     Citation Subset:  AIM; IM    
Department of Psychology, Göteborg University, Box 500, SE-405 30 Göteborg, Sweden.
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MeSH Terms
Age of Onset
Aged, 80 and over
Cognition Disorders / epidemiology*,  mortality,  psychology*
Disease Progression
Likelihood Functions
Models, Psychological
Neuropsychological Tests
Spatial Behavior
Time Factors
Verbal Behavior
Comment In:
Neurology. 2008 Sep 16;71(12):874-5   [PMID:  18794490 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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