| Onset of terminal decline in cognitive abilities in individuals without dementia. | |
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MedLine Citation:
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PMID: 18753475 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To identify time of onset and rate of mortality-related change (terminal decline) in cognitive abilities in later life. METHOD: The sample consisted of 288 individuals without dementia (born 1901-1902) drawn from the population of Göteborg, Sweden. Participants were followed from age 70 until death, with up to 12 measurement occasions on three cognitive abilities. Change-point analysis was performed using an automated piecewise linear mixed modeling approach to identify the inflection point indicating accelerated within-person change related to mortality. A profile likelihood method was used to identify the change point that best fit the data for each of three cognitive abilities. RESULTS: Onset of terminal decline was identified 6.6 years prior to death for verbal ability, 7.8 years for spatial ability, and 14.8 years for perceptual speed. CONCLUSIONS: There is substantial acceleration in cognitive decline many years prior to death among individuals without dementia. Time of onset and rate of terminal decline vary considerably across cognitive abilities. |
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Authors:
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V Thorvaldsson; S M Hofer; S Berg; I Skoog; S Sacuiu; B Johansson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-27 |
Journal Detail:
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Title: Neurology Volume: 71 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-16 Completed Date: 2008-10-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 882-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychology, Göteborg University, Box 500, SE-405 30 Göteborg, Sweden. valgeir.thorvaldsson@psy.gu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Aged Aged, 80 and over Cognition Cognition Disorders / epidemiology*, mortality, psychology* Disease Progression Female Humans Likelihood Functions Male Models, Psychological Neuropsychological Tests Perception Spatial Behavior Time Factors Verbal Behavior |
| Comments/Corrections | |
Comment In:
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Neurology. 2008 Sep 16;71(12):874-5
[PMID:
18794490
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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