Document Detail

Onset of peripheral arterial disease: role of endothelin in endothelial dysfunction.
MedLine Citation:
PMID:  20154344     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Endothelial dysfunction and inflammation are understood to contribute to the onset of peripheral arterial disease (PAD), and endothelin (ET) may play an important role in this process. This study investigated the role of ET in PAD, and its relationships with symptoms, endothelial dysfunction and inflammation. METHODS AND RESULTS: This cross-sectional study enrolled 141 participants: 66 patients with PAD and intermittent claudication, 37 patients with PAD and critical ischemia, and 38 healthy controls aged under 35 years. There were no gender distribution differences between control and diseased groups. Moreover, no differences were observed in age or cardiovascular risk factors distribution between patients with critical ischemia and patients with claudication. Plasma ET concentrations were significantly higher in patients vs. controls (8.76+/-77.1 vs. 6.45+/-0.89 pmol/l, respectively; P=0.002). Nevertheless, patients with claudication exhibited significantly higher plasma ET concentrations vs. patients with critical ischemia (10.97+/-7.9 vs. 4.82+/-2.57 pmol/l, respectively; P<0.001). Otherwise, significantly greater serum concentrations of C-reactive protein (CRP) were observed in patients with critical ischemia vs. patients with claudication (16.94 vs. 4.73 mg/l, respectively; P=0.001) and controls (0.96 mg/l; P=0.001). Plasma concentrations of ET had a modest negative correlation with serum concentrations of CRP (-0.165; P=0.095). CONCLUSION: Plasma concentrations of ET in patients with PAD are greatest in early disease; ET concentrations decrease substantially and inflammation arises as disease advances. Serum CRP concentrations exhibit a modest negative correlation with those of ET.
Joaquín de Haro Miralles; Aurora Flórez Gónzalez; César Varela Casariego; Francisco Acín García
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2010-02-13
Journal Detail:
Title:  Interactive cardiovascular and thoracic surgery     Volume:  10     ISSN:  1569-9285     ISO Abbreviation:  Interact Cardiovasc Thorac Surg     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-08-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158399     Medline TA:  Interact Cardiovasc Thorac Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  760-5     Citation Subset:  IM    
Copyright Information:
2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved.
Vascular Surgery Service, Hospital Universitario de Getafe, Madrid, Spain.
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MeSH Terms
Biological Markers / blood
Cross-Sectional Studies
Disease Progression
Endothelins / blood*,  metabolism
Endothelium, Vascular / metabolism*,  pathology
Follow-Up Studies
Intermittent Claudication / blood,  physiopathology*
Middle Aged
Peripheral Vascular Diseases / blood,  physiopathology*
Risk Assessment
Severity of Illness Index
Time Factors
Reg. No./Substance:
0/Biological Markers; 0/Endothelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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