| Onset of peripheral arterial disease: role of endothelin in endothelial dysfunction. | |
MedLine Citation:
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PMID: 20154344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Endothelial dysfunction and inflammation are understood to contribute to the onset of peripheral arterial disease (PAD), and endothelin (ET) may play an important role in this process. This study investigated the role of ET in PAD, and its relationships with symptoms, endothelial dysfunction and inflammation. METHODS AND RESULTS: This cross-sectional study enrolled 141 participants: 66 patients with PAD and intermittent claudication, 37 patients with PAD and critical ischemia, and 38 healthy controls aged under 35 years. There were no gender distribution differences between control and diseased groups. Moreover, no differences were observed in age or cardiovascular risk factors distribution between patients with critical ischemia and patients with claudication. Plasma ET concentrations were significantly higher in patients vs. controls (8.76+/-77.1 vs. 6.45+/-0.89 pmol/l, respectively; P=0.002). Nevertheless, patients with claudication exhibited significantly higher plasma ET concentrations vs. patients with critical ischemia (10.97+/-7.9 vs. 4.82+/-2.57 pmol/l, respectively; P<0.001). Otherwise, significantly greater serum concentrations of C-reactive protein (CRP) were observed in patients with critical ischemia vs. patients with claudication (16.94 vs. 4.73 mg/l, respectively; P=0.001) and controls (0.96 mg/l; P=0.001). Plasma concentrations of ET had a modest negative correlation with serum concentrations of CRP (-0.165; P=0.095). CONCLUSION: Plasma concentrations of ET in patients with PAD are greatest in early disease; ET concentrations decrease substantially and inflammation arises as disease advances. Serum CRP concentrations exhibit a modest negative correlation with those of ET. |
Authors:
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Joaquín de Haro Miralles; Aurora Flórez Gónzalez; César Varela Casariego; Francisco Acín García |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2010-02-13 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 10 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-08-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 760-5 Citation Subset: IM |
Copyright Information:
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2010 Published by European Association for Cardio-Thoracic Surgery. All rights reserved. |
Affiliation:
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Vascular Surgery Service, Hospital Universitario de Getafe, Madrid, Spain. deharojoaquin@yahoo.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cross-Sectional Studies Disease Progression Endothelins / blood*, metabolism Endothelium, Vascular / metabolism*, pathology Female Follow-Up Studies Humans Intermittent Claudication / blood, physiopathology* Male Middle Aged Peripheral Vascular Diseases / blood, physiopathology* Risk Assessment Severity of Illness Index Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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