| Onset and maintenance of angiogenesis in biomaterials: in vivo assessment by dynamic contrast-enhanced MRI. | |
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MedLine Citation:
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PMID: 19348591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) as a practical tool for longitudinal assessment of angiogenesis in biomaterials. BACKGROUND: There is a lack of suitable methods for in vivo evaluation of the integration of biomaterials in a clinical setting. In oncology, DCE-MRI is used for the longitudinal monitoring of altered tumor angiogenesis during therapy. Thus, we investigated whether DCE-MRI enables to assess the integration of biomaterials over time. METHODS: The tested material was bovine bone matrix applied in a bilateral sinus lift procedure in combination with concentrated mononuclear cells, including mesenchymal stem cells and autologous thrombin. To assess the development of new blood vessels inside the biomaterial, DCE-MRI was carried out before and 11, 25, 53, and 104 days after surgery. Perfusionparameters were calculated according to the model of Tofts. RESULTS: Analysis of the data revealed increasing parameters for perfusion and blood supply within the transplant over time. It was possible to determine the values for each transplantation site and each point of time separately. CONCLUSION: DCE-MRI is appropriate to repetitively survey angiogenesis and integration of biomaterials in patients. It seems appropriate as a valuable indicator of treatment response or failure, with consecutive adaption of the therapy regime. |
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Authors:
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Sebastian Sauerbier; Moritz Palmowski; Michael Vogeler; Heiner Nagursky; Ali Al-Ahmad; Dagmar Fisch; Jürgen Hennig; Rainer Schmelzeisen; Ralf Gutwald; Ulrike Fasol |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Tissue engineering. Part C, Methods Volume: 15 ISSN: 1937-3392 ISO Abbreviation: - Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-01 Completed Date: 2009-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101466663 Medline TA: Tissue Eng Part C Methods Country: United States |
Other Details:
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Languages: eng Pagination: 455-62 Citation Subset: IM |
Affiliation:
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Department of Oral and Craniomaxillofacial Surgery, University Hospital Freiburg, D-79106 Freiburg, Germany. sebastian.sauerbier@uniklinik-freiburg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cells, Cultured Contrast Media Feasibility Studies Female Humans Magnetic Resonance Imaging / methods* Mesenchymal Stem Cell Transplantation / methods* Microvessels / cytology*, growth & development* Neovascularization, Physiologic / physiology* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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