Document Detail

Onset of heart failure determines the hepatic cell death pattern.
MedLine Citation:
PMID:  21502679     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND RATIONALE: Acute and chronic heart failure (HF) may affect the liver, but the underlying mechanisms that lead to progressive liver damage are poorly understood. The hepatic cytokeratin-18 (CK18) epitopes M65 and M30 have been reported to distinguish between overall (necrotic) and apoptotic cell death, respectively. We aimed to evaluate the predominant hepatic cell death pattern in acute vs. chronic heart failure and examined if these assays predict the course of the disease.
MAIN RESULTS: In a prospective study comprising 21 patients with acute HF (AHF) and 18 patients with chronic HF (CHF) serum levels of M65 and M30 were assessed. Compared with CHF, M65 levels were significantly increased in patients with AHF (CHF: 1,283 ± 591.6U/l vs. AHF: 20,912 ± 15,132U/l, p < 0.001). In addition, M30 levels were significantly increased in AHF (CHF: 642.2 ± 177.4U/l vs. AHF: 3,844 ± 5,293U/l, p < 0.05), but the M30/M65 ratio was significantly higher in CHF (CHF: 0.54 ± 0.15 vs. AHF: 0.20 ± 0.19, p < 0.001), indicating a greater contribution of apoptotic cell death in CHF. AHF patients with higher M30 values had a worse prognosis.
CONCLUSIONS: The ratio of CK18 M30/M65 is a potential marker to discriminate AHF from CHF induced LF and M30 might be a prognostic marker for survival in AHF induced liver injury.
Kerstin Herzer; Guntje Kneiseler; Lars Peter Bechmann; Felix Post; Martin Schlattjan; Jan-Peter Sowa; Till Neumann; Günter Marggraf; Raimund Erbel; Guido Gerken; Ali Canbay; Christoph Jochum
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of hepatology     Volume:  10     ISSN:  1665-2681     ISO Abbreviation:  Ann Hepatol     Publication Date:    2011 Apr-Jun
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-08-17     Revised Date:  2013-05-16    
Medline Journal Info:
Nlm Unique ID:  101155885     Medline TA:  Ann Hepatol     Country:  Mexico    
Other Details:
Languages:  eng     Pagination:  174-9     Citation Subset:  IM    
Department for Gastroenterology and Hepatology, University Hospital Essen, Hufelandstr, Germany.
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MeSH Terms
Acute Disease
Apoptosis / physiology*
Biological Markers / blood*
Chronic Disease
Epitopes / metabolism
Heart Failure* / blood,  mortality,  pathology
Keratin-18 / blood*
Liver / pathology
Liver Diseases* / blood,  mortality,  pathology
Middle Aged
Predictive Value of Tests
Prospective Studies
Survival Analysis
Reg. No./Substance:
0/Biological Markers; 0/Epitopes; 0/Keratin-18

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