Document Detail


Onset and duration of protective immunity to IA/IB and IE strains of Venezuelan equine encephalitis virus in vaccinated mice.
MedLine Citation:
PMID:  11672929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three vaccines developed for protection against IA/IB subtypes of Venezuelan equine encephalitis (VEE) virus were evaluated in mice for the ability to protect against systemic and mucosal challenges with a virulent virus of the IE subtype. The vaccines were the formaldehyde-inactivated C-84 and live attenuated TC-83 vaccines currently administered to people under investigational new drug (IND) status, and a new live attenuated vaccine candidate, V3526. V3526 was superior for inducing protection to VEE IA/IB within a week of vaccination, and protection persisted for at least a year. All three vaccines induced long-term clinical protection against peripheral or mucosal challenge with IE virus, with the mucosal immunity induced by attenuated vaccines lasting longer than that induced by the inactivated vaccine. These data show that the molecularly cloned V3526 vaccine induces equivalent or improved immunity to homologous and heterologous VEE viruses than the existing vaccines.
Authors:
M K Hart; C Lind; R Bakken; M Robertson; R Tammariello; G V Ludwig
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vaccine     Volume:  20     ISSN:  0264-410X     ISO Abbreviation:  Vaccine     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-23     Completed Date:  2002-01-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8406899     Medline TA:  Vaccine     Country:  England    
Other Details:
Languages:  eng     Pagination:  616-22     Citation Subset:  IM    
Affiliation:
Virology Division and Toxinology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA. marykate.hart@amedd.army.mil
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Viral / blood
Encephalitis Virus, Venezuelan Equine / classification,  immunology*
Female
Mice
Mice, Inbred BALB C
Time Factors
Vaccination
Viral Vaccines / immunology*
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Viral Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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