Document Detail

Onset of cell proliferation in the shortened gut: growth after subtotal colectomy.
MedLine Citation:
PMID:  982279     Owner:  NLM     Status:  MEDLINE    
Cell proliferation and remodeling of the small intestine were studied after subtotal colectomy in the rat. After an initial fall in nucleic acid contents, there was a trend to increasing amounts of RNA throughout the intestine on the fourteenth postoperative day; by the thirtieth day RNA and DNA contents were increased about 20 percent. DNA synthesis increased after 5 days. Although initially villi became shorter and crypts shallower, higher villi, deeper crypts, and an increased rate of cell migration were present after 14 days. Subtotal colectomy stimulates nucleic acid synthesis and remodeling of the small bowel within 2 weeks. Changes are more marked in ileum.
T W Buchholtz; D Malamud; J S Ross; R A Malt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Surgery     Volume:  80     ISSN:  0039-6060     ISO Abbreviation:  Surgery     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0417347     Medline TA:  Surgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  601-7     Citation Subset:  AIM; IM    
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MeSH Terms
Cell Movement
DNA / metabolism
Ileum / metabolism
Intestinal Mucosa / cytology,  metabolism
Intestine, Small / cytology,  physiology*
Jejunum / metabolism
RNA / metabolism
Reg. No./Substance:
63231-63-0/RNA; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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