Document Detail

Onset of acquired autoimmune hypothyroidism in infancy: a presentation of delayed gross-motor development and rhabdomyolysis.
MedLine Citation:
PMID:  16429278     Owner:  NLM     Status:  MEDLINE    
We report the case of a 23-month-old girl who presented with poor growth and delayed attainment of gross-motor milestones. Elevated creatine phosphokinase (CPK) indicated rhabdomyolysis, ultimately attributed to severe, acquired autoimmune hypothyroidism. Growth data and bone-age suggest the onset of hypothyroidism occurred at or before 12 months of age. Acquired hypothyroidism is rare before age 3 years, and rhabdomyolysis due to hypothyroidism has not previously been reported as a cause of delayed gross-motor development in toddlerhood. Despite the early onset of hypothyroidism, cognitive function appeared to be unaffected. Adequate thyroid hormone replacement quickly normalized the CPK in our patient, and gross motor development rapidly improved. Although rare, rhabdomyolysis secondary to hypothyroidism should be in the differential diagnosis of delayed gross-motor development in infancy and toddlerhood.
Daniel F Gunther; Harvey K Chiu; Thomas E Numrych; Gad B Kletter
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-01-21
Journal Detail:
Title:  European journal of pediatrics     Volume:  165     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-03-24     Completed Date:  2006-11-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  320-2     Citation Subset:  IM    
Division of Pediatric Endocrinology, Children's Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, WA 98105, USA.
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MeSH Terms
Antibodies / blood
Autoimmune Diseases / diagnosis*,  drug therapy
Creatine Kinase / blood
Developmental Disabilities / drug therapy,  etiology*
Hormone Replacement Therapy
Hypothyroidism / diagnosis*,  drug therapy,  immunology
Peroxidase / immunology
Rhabdomyolysis / drug therapy,  etiology*
Thyroglobulin / immunology
Thyroxine / therapeutic use
Reg. No./Substance:
0/Antibodies; 7488-70-2/Thyroxine; 9010-34-8/Thyroglobulin; EC; EC Kinase

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