| Onset of acquired autoimmune hypothyroidism in infancy: a presentation of delayed gross-motor development and rhabdomyolysis. | |
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MedLine Citation:
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PMID: 16429278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report the case of a 23-month-old girl who presented with poor growth and delayed attainment of gross-motor milestones. Elevated creatine phosphokinase (CPK) indicated rhabdomyolysis, ultimately attributed to severe, acquired autoimmune hypothyroidism. Growth data and bone-age suggest the onset of hypothyroidism occurred at or before 12 months of age. Acquired hypothyroidism is rare before age 3 years, and rhabdomyolysis due to hypothyroidism has not previously been reported as a cause of delayed gross-motor development in toddlerhood. Despite the early onset of hypothyroidism, cognitive function appeared to be unaffected. Adequate thyroid hormone replacement quickly normalized the CPK in our patient, and gross motor development rapidly improved. Although rare, rhabdomyolysis secondary to hypothyroidism should be in the differential diagnosis of delayed gross-motor development in infancy and toddlerhood. |
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Authors:
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Daniel F Gunther; Harvey K Chiu; Thomas E Numrych; Gad B Kletter |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-01-21 |
Journal Detail:
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Title: European journal of pediatrics Volume: 165 ISSN: 0340-6199 ISO Abbreviation: Eur. J. Pediatr. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-03-24 Completed Date: 2006-11-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7603873 Medline TA: Eur J Pediatr Country: Germany |
Other Details:
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Languages: eng Pagination: 320-2 Citation Subset: IM |
Affiliation:
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Division of Pediatric Endocrinology, Children's Hospital and Regional Medical Center, University of Washington School of Medicine, Seattle, WA 98105, USA. Dan.gunther@seattlechildrens.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies
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blood Autoimmune Diseases / diagnosis*, drug therapy Creatine Kinase / blood Developmental Disabilities / drug therapy, etiology* Female Hormone Replacement Therapy Humans Hypothyroidism / diagnosis*, drug therapy, immunology Infant Peroxidase / immunology Rhabdomyolysis / drug therapy, etiology* Thyroglobulin / immunology Thyroxine / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 7488-70-2/Thyroxine; 9010-34-8/Thyroglobulin; EC 1.11.1.7/Peroxidase; EC 2.7.3.2/Creatine Kinase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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