| Onset of Kleine-Levin Syndrome in association with isotretinoin treatment. | |
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MedLine Citation:
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PMID: 20163374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The synthetic retinoid isotretinoin is an effective treatment option for severe forms of acne vulgaris. However, several reports indicate that some patients experience altered central nervous system functions in association with treatment. We present here the first description of the onset of Kleine-Levin Syndrome (KLS), a rare disorder characterised by periodic hypersomnia and cognitive and behavioural symptoms, in close temporal relation to the start of isotretinoin treatment. We also discuss the biological potential of retinoids to affect sleep. CONCLUSIONS: In light of a documented potential of retinoids to modulate sleep-wake regulation, the present case suggests that isotretinoin may rarely trigger the onset of KLS. |
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Authors:
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H Smedje; S Schwan; E Hallberg; P Hallberg |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-16 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 99 ISSN: 1651-2227 ISO Abbreviation: Acta Paediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-17 Completed Date: 2010-08-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 946-8 Citation Subset: IM |
Affiliation:
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Child and Adolescent Psychiatric Unit, Department of Neuroscience, Uppsala University Hospital, Uppsala, Sweden. hans.smedje@neuro.uu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acne Vulgaris
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drug therapy Adolescent Dermatologic Agents / adverse effects* Humans Isotretinoin / adverse effects* Kleine-Levin Syndrome / chemically induced*, diagnosis Male |
| Chemical | |
Reg. No./Substance:
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0/Dermatologic Agents; 4759-48-2/Isotretinoin |
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