Document Detail


Online hemodiafiltration: 4 years of clinical experience.
MedLine Citation:
PMID:  16441865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Online hemodiafiltration (online HDF) is a new hemodialysis technique combining convection and diffusion and thus also enabling the purification of large molecules. As yet, only a small number of clinical experiences have been published about the effectiveness and safety of online HDF. We present a prospective and observational study conducted on 31 patients treated with online HDF in our center in the last 4 years. The purpose of the study is to compare the evolution of the following aspects before and after starting online HDF: dose of dialysis, purification of medium-sized/large molecules, inflammation, nutrition, Ca-P metabolism, anemia, and intradialytic complications. Online HDF increased Kt/V to 31.0% (p > 0.001) and reduced postdialysis beta(2)-M to 66.4% (p > 0.001). The rest of the parameters analyzed did not vary significantly. During online HDF, episodes of symptomatic hypotension fell by 45% in relation to conventional hemodialysis, and no relevant complication occurred. Online HDF is very useful in patients in whom we need to increase replacement therapy, such as patients with a large body surface, those in whom we suspect a residual syndrome or those who have been receiving dialysis for a long time and for whom we wish to prevent amyloidosis. Online HDF is safe and better tolerated than conventional hemodialysis.
Authors:
Rosa Muñoz; Isabel Gallardo; Evandro Valladares; Ramón Saracho; Isabel Martínez; Julen Ocharan; Jesús Montenegro
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Hemodialysis international. International Symposium on Home Hemodialysis     Volume:  10 Suppl 1     ISSN:  1492-7535     ISO Abbreviation:  Hemodial Int     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2006-01-30     Completed Date:  2006-05-03     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  101093910     Medline TA:  Hemodial Int     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  S28-32     Citation Subset:  IM    
Affiliation:
Nephrology Department, Hospital de Galdakao, Galdakao-Vizcaya, Spain. rmunoz@hgda.osakidetza.net
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Anemia / etiology
Calcium Phosphates / metabolism
Female
Hemodiafiltration / adverse effects,  instrumentation*,  methods
Humans
Hypotension / etiology
Inflammation / etiology
Longitudinal Studies
Male
Middle Aged
Nutritional Physiological Phenomena
Online Systems*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Calcium Phosphates; 97Z1WI3NDX/calcium phosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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