Document Detail

Online correlation of spontaneous arterial and intracranial pressure fluctuations in patients with diffuse severe head injury.
MedLine Citation:
PMID:  17806207     Owner:  NLM     Status:  MEDLINE    
Determination of relevant clinical monitoring parameters for helping guide the intensive care therapy in patients with severe head injury, is one of the most demanding issues in neurotrauma research. New insights into cerebral autoregulation and metabolism have revealed that a rigid cerebral perfusion pressure (CPP) regimen might not be suitable for all severe head injured patients. We thus developed an online analysis technique to monitor the correlation (AI rho) between the spontaneous fluctuations of the mean arterial blood pressure (MABP) and the intracranial pressure (ICP). In addition, brain tissue oxygen (PtiO2) and metabolic microdialysate measures including glucose and lactate were registered. We found that in patients with good outcome, the AI rho values were significantly lower as compared with patients with poor outcome. Accordingly, microdialysate glucose and lactate were significantly higher in the good outcome group. We conclude that online determination of AI rho offers a valuable additional and technically easily performable tool for guidance of therapy in patients with severe head injury.
Michael Reinert; Robert H Andres; Martin Fuhrer; Alexander Müller; Benoit Schaller; HansRuedi Widmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  29     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-09-05     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  455-62     Citation Subset:  IM    
Department of Neurosurgery, Inselspital Bern, University of Bern, 3010 Bern, Switzerland.
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MeSH Terms
Arteries / physiopathology*
Blood Pressure / physiology*
Brain Injuries / metabolism,  pathology*,  physiopathology*
Glucose / metabolism
Intracranial Pressure / physiology*
Lactic Acid / metabolism
Microdialysis / methods
Middle Aged
Monitoring, Physiologic
Online Systems
Severity of Illness Index
Statistics, Nonparametric
Tomography Scanners, X-Ray Computed
Reg. No./Substance:
50-21-5/Lactic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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